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Burkholderia

Burkholderia is a genus of Pseudomonadota whose pathogenic members include the Burkholderia cepacia complex, which attacks humans and plants; Burkholderia mallei, responsible for glanders, a disease that occurs mostly in horses and related animals; Burkholderia pseudomallei, causative agent of melioidosis; and Burkholderia cenocepacia, an important pathogen of pulmonary infections in people with cystic fibrosis (CF). Burkholderia species is also found in marine environments. S.I. Paul et al. isolated and characterized Burkholderia cepacia from marine sponges of the Saint Martin's Island of the Bay of Bengal, Bangladesh.

History
The genus was named after Walter H. Burkholder, plant pathologist at Cornell University. The first species placed in the genus were transfers from Pseudomonas, on the basis of various biochemical tests. However, the genus Paraburkholderia is phylogenetically distinct, and can be distinguished from all Burkholderia species on the basis of molecular signatures that are uniquely found for each genus. ==Taxonomy==
Taxonomy
Burkholderia species form a monophyletic group within the Burkholderiales order of the Betaproteobacteria. == Research ==
Research
Recently, research in Burkholderia species has investigated a range of topics and characteristics including metabolomic response to antibiotics, contact-dependent interactions between bacterial communities, and genomic potential to yield beneficial products. In Burkholderia species, certain antibiotics such as trimethoprim has been shown to induce and upregulate a large amount of the metabolome, inducing over 100 silent secondary metabolite gene clusters in Burkholderia thailandensis. Research focused on interbacterial signaling using Burkholderia has shown that contact-dependent growth inhibition plays a significant role in mediating cell to cell communication specifically in B. thailandensis. Thus, contact-dependent signaling plays a significant role in bacterial self recognition and community formation. Along with the related genus Pseudomonas, Burkholderia can synthesize a particular class of biosurfactant called rhamnolipids. Rhamnolipids synthesized by Burkholderia have differing chemical characteristics (compared to those synthesized by Pseudomonas) and thus have the potential for novel applications. ==Species==
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