SR 6 was established at least as early as 1919 from SR 1 in Cedartown east-southeast through Dallas to SR 8 in Austell. By the end of September 1921, it was extended westward to the Alabama state line. By October 1926, US 78 was designated on SR 8 at SR 6's eastern terminus. About 20 years later, between the beginning of 1945 and November 1946, the entire segment from Alabama to Austell was hard surfaced. Between June 1954 and June 1955, US 278 was designated on the entire original segment. Between June 1963 and the end of 1965, SR 6 was extended south-southwest on US 78/SR 8 to a point south-southwest of Austell and then on a sole path southeast to I-20; this entire extension was hard surfaced. At this time, Camp Creek Parkway was established from Welcome All Road west-southwest of College Park to US 29/SR 14 in the city. Between the beginning of 1963 and the beginning of 1969, a northern
bypass of the main part of Rockmart was built from US 278/SR 6 west-northwest of the city to SR 113 in the northwestern part of the city. By the beginning of 1974, an eastern bypass of the main part of Rockmart was proposed from US 278/SR 6/SR 100 southeast of Van Wert north-northwest and north to SR 113 in the northwest part of Rockmart. In 1976, SR 139 was rerouted westward just west of the Atlanta Airport, onto the path of US 29/SR 14. Due to this, Camp Creek Parkway was extended eastward to I-85. Between the beginning of 1979 and March 1980, Camp Creek Parkway was extended westward to Old Fairburn Road and northwest to Butner Road. Between the beginning of 1979 and the beginning of 1982, SR 6's path in Cedartown was shifted westward one block, replacing the entire length of
SR 6 Loop. In 1983, a western bypass of Powder Springs,
Clarkdale, and Austell, designated as
SR 726, was proposed from an unnumbered road south-southwest of Powder Springs to US 78/SR 5/SR 8 southwest of Austell. In 1986, a slightly northern rerouting of US 278/SR 6 was proposed from just east of the Paulding–Cobb county line to the northern part of Powder Springs. US 278/SR 6 in the Powder Springs–Austell area was shifted westward, onto the path of SR 726 and the northern part of the unnumbered road in Powder Springs. The former path from Powder Springs to Austell was redesignated as
SR 6 Bus. Camp Creek Parkway was extended north-northwest to connect with the eastern terminus of SR 6. The next year,
SR 744 Spur was proposed from US 27/SR 1/SR 100 in the southern part of Cedartown to the proposed path of
SR 744 southeast of it. Part of the eastern bypass of Rockmart, designated as
SR 748, was proposed from SR 113 east-northeast of the city south and south-southeast to US 278/SR 6 east-southeast of Van Wert. A northeastern bypass of
Yorkville, designated as
SR 789, was proposed from north-northeast of Yorkville to east of it. A southern bypass of Dallas, designated as
SR 768, was proposed from west-southwest of Dallas to US 278/SR 6/SR 120 southeast of it; this replaced the proposed path of
SR 6 Byp. In 1988, a proposed northern rerouting of US 278/SR 6 was designated as a second iteration of SR 726. In 1990, US 278/SR 6 was shifted northeast from Van Wert on SR 113 and southeast on the proposed path of SR 748, with SR 101/SR 113 concurrent with them to Yorkville. US 278/SR 6/SR 120 was routed on the proposed path of SR 768. At this time, SR 726 was completed. Also, Camp Creek Parkway's path between I-285 and I-85 was designated as
SR 387. The next year, the path of US 278/SR 6 in Cedartown was shifted southward from the central part of the city to the southern part, onto the proposed path of SR 744 Spur. US 278/SR 6, as well as part of US 27/SR 1, was routed onto parts of the former path of SR 744. US 278/SR 6 in Rockmart was shifted northward onto a more direct path just north of the city. US 278/SR 6 in the Powder Springs area was shifted northward, onto the former path of SR 726. Also, SR 387 was
decommissioned. In 1987, SR 6 was extended on the entire length of Camp Creek Parkway, to its eastern terminus. On March 14, 1984, US 278 and SR 6, between
Powder Springs and
Austell, was designated as the 'C. H. (Fat) James, Sr., Memorial Highway'. Recently, at the intersection of SR 6 and I-285 in East Point, there has been a renaissance for southern
Fulton County: the opening of the Camp Creek MarketPlace. It was opened in late 2003, and the second portion opened in spring or summer of 2006. On August 1, 2008, Camp Creek Parkway, the stretch of SR 6, between
SR 70 and
I-85, was honorarily designated Tuskegee Airmen Parkway. As of March 2009, the portion of the highway in Fulton County is no longer signed as SR 6. The only signage on this route are the Tuskegee Airmen Parkway signs. The portion near I-285 and the Atlanta Airport, which is in Clayton County, is still signed as SR 6. ==Major intersections==