In 1503, the new bishop
Christoph von Utenheim refused to give Basel a new constitution whereupon, to show its power, the city began the construction of a new city hall. The reformation was brought to Basel by
Johannes Oecolampadius cathedral preacher under von Utenheim and co-editor of Erasmus'
first edition of the Greek New Testament. Von Utenheim resigned on 19 February 1527. He was succeeded by
Philippe von Gundelsheim, canon at Basel Münster since 1510. In 1529, the city became Protestant under
Oecolampadius and the bishop's seat was moved to Porrentruy. In 1530,
Laufental rebelled against the bishop, but were suppressed using forces from
Solothurn. Because of insolvency, the prince-bishopric grew increasingly dependent on the city of Basel, with the city granting him a mortgage on
Birseck Castle in 1542, 1544, and 1545. In 1547, the bishop formally agreed to allow the city to choose its own religion, recognizing that the city had already become Protestant. The Basel patriciate (
"Daig") now played a pivotal role in city affairs as they gradually established themselves as a
de facto city aristocracy. The
Bernoulli family, which included important 17th- and 18th-century mathematicians such as
Jakob Bernoulli,
Johann Bernoulli and
Daniel Bernoulli, were from Basel. The 18th-century mathematician
Leonhard Euler was born in Basel and studied under Johann Bernoulli. Intended as a defence of
Huguenots then persecuted in France, Calvin's
Institutes, authored in Basel, was a 1536 exposition of Protestant Christian doctrine which later became known as
Calvinism. , oriented with SW at the top and NE at the bottom. The first edition of
Christianae religionis institutio (
Institutes of the Christian Religion –
John Calvin's great exposition of
Calvinist doctrine) was published at Basel in March 1536. In 1543,
De humani corporis fabrica, the first book on human anatomy, was published and printed in Basel by
Andreas Vesalius (1514–1564). The 1648
Peace of Westphalia finally brought about Imperial recognition of the independence of the
Swiss cantons, removing the
de jure (but not
de facto) overlordship of the
Holy Roman Empire rejected by the then–Prince-Bishopric nearly 150 years earlier. == Unrest and insurrection ==