List of neurosteroids

Natural Cholestanes • 25-Hydroxycholesterol: cholest-5-en-3β,25-diol – NMDA receptor negative allosteric modulator Androstanes • 3α,5α-Androstanediol (3α-androstanediol): 5α-androstane-3α,17β-diol – GABAA receptor positive allosteric modulator • 3α,5β-Androstanediol (etiocholanediol): 5β-androstane-3α,17β-diol – GABAA receptor positive allosteric modulator • 3α-Androstenol: 5α-androst-16-en-3α-ol – GABAA receptor positive allosteric modulator • Androsterone: 5α-androstan-3α-ol-17-one – GABAA receptor positive allosteric modulator • Etiocholanolone: 5β-androstan-3α-ol-17-one – GABAA receptor positive allosteric modulator • Allopregnanolone (brexanolone; SAGE-547): 5α-pregnan-3α-ol-20-one – GABAA receptor positive allosteric modulator • Dihydrodeoxycorticosterone (DHDOC): 21-hydroxy-5α-pregnan-20-one – GABAA receptor positive allosteric modulator • Pregnanediol: 5β-pregnan-3α,20α-diol – GABAA receptor positive allosteric modulator • Ganaxolone: 3β-methyl-5α-pregnan-3α-ol-20-one – GABAA receptor positive allosteric modulator • Hydroxydione: 21-hydroxy-5β-pregnane-3,20-dione – GABAA receptor positive allosteric modulator • Minaxolone: 11α-(dimethylamino)-2β-ethoxy-5α-pregnan-3α-ol-20-one – GABAA receptor positive allosteric modulator • ORG-20599: 21-chloro-2β-morpholin-4-yl-5β-pregnan-3α-ol-20-one – GABAA receptor positive allosteric modulator • ORG-21465: 2β-(2,2-dimethyl-4-morpholinyl)-3α-hydroxy-11,20-dioxo-5α-pregnan-21-yl methanesulfonate – GABAA receptor positive allosteric modulator • Posovolone (Co 134444): 3β-Hydroxy-21-(1H-imidazol-1-yl)-3α-(methoxymethyl)-5α-pregnan-20-one – GABAA receptor positive allosteric modulator • Renanolone: 5β-pregnan-3α-ol-11,20-dione – GABAA receptor positive allosteric modulator • SGE-516 – GABAA receptor positive allosteric modulator The following are proneurosteroids: • EIDD-1723 – of EIDD-036 (see above) • Progesterone carboxymethyloxime (P4-3-CMO) – of progesterone and by extension pregnanediones, pregnanolones, and pregnanediols (see above) ==Excitatory==

Natural Cholestanes • Cerebrosterol (24(S)-Hydroxycholesterol): cholest-5-en-3β,24S-diol – NMDA receptor positive allosteric modulator Pregnanes • 3β-Dihydroprogesterone (3β-DHP): pregn-4-en-3β-ol-20-one – GABAA receptor negative allosteric modulator • Epipregnanolone: 5β-pregnan-3β-ol-20-one – GABAA receptor negative allosteric modulator • Isopregnanolone (sepranolone): 5α-pregnan-3β-ol-20-one – GABAA receptor negative allosteric modulator • Pregnenolone sulfate (PS): pregn-5-en-3β-ol-20-one 3β-sulfate – GABAA receptor negative allosteric modulator, NMDA receptor positive allosteric modulator, sigma-1 receptor agonist, TRPM3 agonist, other actions The following are proneurosteroids: • Pregnenolone (P5): pregn-5-en-3β-ol-20-one – of pregnenolone sulfate Androstanes • Dehydroepiandrosterone (DHEA; prasterone): androst-5-en-3β-ol-17-one – GABAA receptor positive allosteric modulator, NMDA receptor positive allosteric modulator, sigma-1 receptor agonist, other actions • Dehydroepiandrosterone sulfate (DHEA-S; prasterone sulfate): androst-5-en-3β-ol-17-one 3β-sulfate – GABAA receptor negative allosteric modulator, NMDA receptor positive allosteric modulator, other actions Synthetic Androstanes • 17-Phenylandrostenol (17-PA): 17-phenyl-5α-androst-16-en-3α-ol – GABAA receptor negative allosteric modulator • Golexanolone (GR-3027): 3α-ethynyl-3β-hydroxyandrostan-17E-one oxime – GABAA receptor negative allosteric modulator Others • SAGE-201 - oxysterol/cholesterol analogue – NMDA receptor positive allosteric modulator • SAGE-301 - oxysterol/cholesterol analogue – NMDA receptor positive allosteric modulator • SAGE-718: oxysterol/cholesterol analogue; exact chemical structure undisclosed – NMDA receptor positive allosteric modulator ==Mixed==

Natural Cholestanes • Cholesterol: cholest-5-en-3β-ol – NMDA receptor positive allosteric modulator, possible GABAA receptor positive allosteric modulator, many other actions Pregnanes • Epipregnanolone sulfate: 5β-pregnan-3β-ol-20-one 3β-sulfate – GABAA and NMDA receptor negative allosteric modulator, TRPM3 agonist ==Neurotrophic==

Natural Androstanes • Dehydroepiandrosterone (DHEA; prasterone): androst-5-en-3β-ol-17-one – TrkA, TrkC, and p75NTR agonist, TrkB ligand • Dehydroepiandrosterone sulfate (DHEA-S; prasterone sulfate): androst-5-en-3β-ol-17-one 3β-sulfate – TrkA and p75NTR agonist Ergostanes • Anicequol (NGA0187, NGD-187): 16β-acetoxy-3β,7β,11β-trihydroxy-5α-ergost-22(E)-en-6-one – non-endogenous; fungi-derived; undefined mechanism of action; shows neurotrophic activity in vitro; was formerly under development for the treatment of cognitive disorders Synthetic Androstanes • BNN-20: 17β-spiro-(androst-5-en-17,2'-oxiran)-3β-ol – TrkA, TrkB, and p75NTR agonist Pregnanes • BNN-27: 17α,20R-epoxypregn-5-ene-3β,21-diol – TrkA and p75NTR agonist ==Antineurotrophic==

Natural Androstanes • Testosterone: androst-4-en-17β-ol-3-one – TrkA and p75NTR antagonist Synthetic Pregnanes • Dexamethasone: 9α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione – TrkA and p75NTR antagonist ==Pheromones and pherines==

Natural Androstanes • 3α-Androstenol: 5α-androst-16-en-3α-ol • 3β-Androstenol: 5α-androst-16-en-3β-ol • Androstadienol: androsta-5,16-dien-3β-ol • Androstadienone: androsta-4,16-dien-3-one • Androstenone: 5α-androst-16-en-3-one • Androsterone: 5α-androstan-3α-ol-17-one Estranes • Estratetraenol: estra-1,3,5(10),16-tetraen-3-ol Synthetic Androstanes • Fasedienol (Aloradine; PH94B; 4-androstadienol): androsta-4,16-dien-3β-ol Estranes • Estratetraenyl acetate (ETA): estra-1,3,5(10),16-tetraen-3-yl acetate Pregnanes • Pregnadienedione (PDD): pregna-4,20-dien-3,6-dione Others • PH10, PH15, PH30, PH56, PH78, PH84, Salubrin (PH80) – pherines with undefined structures developed by a company called Pherin Pharmaceuticals ==Others==

Natural Pregnanes • Pregnenolone (P5): pregn-5-en-3β-ol-20-one – MAP2 ligand • Progesterone (P4): pregn-4-ene-3,20-dione – sigma-1 receptor antagonist, nicotinic acetylcholine receptor negative allosteric modulator, MAP2 ligand, other actions Spirostanes • Caprospinol (SP-233; diosgenin 3-caproate): (22R,25R)-20α-spirost-5-en-3β-yl hexanoate – β-amyloid ligand, sigma-1 receptor ligand, other actions; found naturally in Gynura japonica; under development as a neuroprotective against Alzheimer's disease Estranes • Estradiol (E2): Estra-1,3,5(10)-triene-3,17β-diol; found to increase the expression of the oxytocin receptor. Synthetic Pregnanes • 3β-Methoxypregnenolone (MAP-4343): 3β-methoxypregn-5-en-20-one – MAP2 ligand • Cyclopregnol (neurosterone): 6β-hydroxy-3:5-cyclopregnan-20-one – undefined mechanism of action; developed as a "psychotropic agent" for the treatment of "mental disorders" such as schizophrenia in the 1950s Androstanes • Cetadiol: androst-5-ene-3β,16α-diol – undefined mechanism of action; developed as a "tranquilizer" and for the treatment of alcoholism in the 1950s ==See also==