Schedule Note: Intra-division opponents are in
bold text.
Game summaries Week 1: at New Orleans Saints Even though quarterback
Kyler Murray was feeling ill when he awoke that day he passed for 163 yards, 21/29 attempts, and 2 touchdowns. Despite getting shut out in the fourth quarter, the Cardinals held on to secure a 1–0 record. It was the Cardinals' first win in New Orleans since the
1996 season.
Week 2: vs. Carolina Panthers Despite taking a 27–3 lead into the fourth quarter, the Cardinals had to fend off a late Panthers comeback. Defensive end
Calais Campbell sealed the 27–22 victory with a game-ending sack on Panthers quarterback
Bryce Young, allowing Arizona to hold on for the win. This would turn out to be the Cardinals’ only home win of the season.
Week 3: at San Francisco 49ers With the loss on a last second field goal, the Cardinals fell to 2–1. During the second half star running back
James Conner was lost for the season with a gruesome ankle injury.
Week 4: vs. Seattle Seahawks With their eighth consecutive loss to the Seahawks, and the second consecutive on a last second field goal, the Cardinals fell to 2–2.
Week 5: vs. Tennessee Titans The Cardinals blew a 21–3 lead and suffered an embarrassing defeat, falling to 2–3 on the season. Arizona led 21–6 entering the fourth quarter before a series of critical mistakes shifted momentum. Running back
Emari Demercado appeared to have all but sealed the game with a 72-yard touchdown run with 12:51 remaining, but he dropped the ball just before crossing the goal line, resulting in a touchback. Later in the quarter, safety
Dadrion Taylor-Demerson intercepted a pass from
Cam Ward but immediately fumbled. Titans receiver
Tyler Lockett recovered the ball in the end zone, cutting the Cardinals' lead to 21–19 with 4:51 left. After a subsequent punt, the Cardinals allowed the Titans to drive down the field, setting up a 29-yard game-winning field goal by
Joey Slye as time expired. The Titans won 22–21, snapping a 10-game losing streak and giving rookie quarterback Cam Ward his first NFL victory. The game also marked the first time in NFL history that a team lost three consecutive games on a field goal as time expired. It was the Cardinals' first home loss to the Titans since the
1997 season, when the franchise was known as the Tennessee Oilers. On the sideline, head coach Jonathan Gannon lectured Demercado before seemingly hitting him in the arm. Gannon later apologized to Demercado and was fined $100,000 by the team.
Week 6: at Indianapolis Colts Jacoby Brissett started in place of an injured Kyler Murray. Despite a close game, Arizona would find themselves yet again on the losing end, suffering their 4th straight loss falling to 2–4.
Week 7: vs. Green Bay Packers Despite leading for most of the game, the Cardinals allowed Packers running back
Josh Jacobs to score the go-ahead touchdown with under two minutes remaining. Arizona attempted a final comeback, but a critical sack by defensive end
Micah Parsons ended any chance of a rally, sealing the Cardinals' fifth consecutive loss. The Cardinals became the first team in NFL history to lose three consecutive games after leading by 7 or more points entering the fourth quarter. Arizona joined the
2017 49ers and the
1984 Browns as the only teams in NFL history to lose five straight games by four points or fewer. Their five-game losing streak came by a combined total of just 13 points.
Week 9: at Dallas Cowboys With their fourth win against Dallas since
2020, the Cardinals snapped their 5-game losing streak and improved to 3–5.
Week 10: at Seattle Seahawks With their ninth loss to the Seahawks, the Cardinals were swept by Seattle for the fourth year in a row and fell to 3–6.
Week 11: vs. San Francisco 49ers The Cardinals were called for a franchise-record 17 penalties, the most by any NFL team prior to Week 15. Despite
Jacoby Brissett recording an NFL-record 47 completions, it was not enough, as Arizona was blown out by the 49ers.
Week 12: vs. Jacksonville Jaguars The Cardinals lost a close game in
overtime 27–24. Despite intercepting
Trevor Lawrence 3 times and recording 4 turnovers the Cardinals still lost. This marked their first loss to Jacksonville since
2005, snapping a 4 game win streak. The Cardinals scored their first points on a
Walter Nolen III 7 yard fumble return.
Bam Knight scored on a 1-yard rush in the second quarter.
Greg Dortch caught a 39-yard pass from
Jacoby Brissett in the fourth quarter. The Cardinals recorded 3 interceptions; one each by
Akeem Davis,
Garrett Williams, and
Budda Baker. Brisket completed 33 of 49 passes for 317 yards and a touchdown and a passer rating of 92.0.
Week 13: at Tampa Bay Buccaneers With their 9th loss in their last 10 games, the Cardinals fell to 3–9 (2–1 against the NFC South) and they were eliminated from playoff contention for the fourth straight season. A few days later Kyler Murray would be ruled out for the rest of the season.
Week 14: vs. Los Angeles Rams With their fifth straight loss, the Cardinals fell to 3–10 and 0–5 against the NFC West.
Week 15: at Houston Texans With their sixth straight loss, the Cardinals fell to 3–11 and became the only NFC West team to get swept by the AFC South.
Week 16: vs. Atlanta Falcons With their seventh straight loss, the Cardinals fell to 3–12, finished 2–2 against the NFC South and 2–6 against both southern divisions. Arizona finished 1–7 at home.
Week 17: at Cincinnati Bengals With the loss, the Cardinals fell to 3–13 and finished 0–5 against the AFC. Tight end
Trey McBride recorded 10 receptions, giving him 119 on the season and breaking the NFL single-season receptions record for a tight end. He surpassed the previous mark of 116 set by
Zach Ertz in 2018.
Week 18: at Los Angeles Rams With the loss, the Cardinals finished dead last in the NFC with a Super Bowl era-franchise worst 3–14 record (2–7 on the road). Additionally, the Cardinals were swept by all three of their NFC West division rivals (for 0–6 division record) for the second time in three seasons. The following day, the Cardinals fired head coach
Jonathan Gannon. During his three-year tenure, Gannon compiled a 15–36 record.
Standings Division Conference == Notes ==