Irsay-Gordon first worked for the Colts in the ticket office and was subsequently involved in the marketing department and the strategies used by the sales team and ticket office. She was made a team vice-president in 2008, while studying for a doctoral degree in clinical psychology. Irsay-Gordon's father,
Jim Irsay, stated that he intended the team to entirely pass to his daughters. Irsay-Gordon was then named as chair of the Colts in March 2014 shortly after Jim Irsay was arrested and entered a rehabilitation facility for drug use. She continues in a similar capacity into 2024 as a member of the NFL's Media Owned and Operated Committee, which oversees operations of the
NFL Network and
NFL.com. She is also a member of the league's Security and Fan Conduct Committee and on the board of the NFL Player Care Foundation, which provides social services to former players of the NFL. After her father's death in May 2025, the Colts announced that Irsay-Gordon would assume the titles of owner and CEO of the team. During the
2025 NFL season, Irsay-Gordon was noted for her hands-on approach as CEO, wearing a headset and holding a playcalling sheet on the Colts' sidelines during games. In a press conference during which she was asked about her unorthodox ownership style, she responded, "I need to learn more about this... I need to be able to say, 'Is this person full of
BS? Do they even know what they're talking about?' ... It's such a complex organism, a football team, and how it operates on game day." Some players have said she knows personal details about their lives and develops genuine relationships with staff. Linebacker
Zaire Franklin noted, "There's a comfortability because we're so familiar. But, make no mistake, she's in charge." ==Philanthropy==