Isles took up the sport of rugby in 2012. On February 29, 2020, Isles became the first ever USA player to score 200 tries. He completed this feat in a 19–17 victory match against
Samoa during the
2019-20 World Rugby Sevens Series in
Los Angeles.
Season by season The following table shows Isles' scoring by season on the World Rugby Sevens Series, as of July 19, 2022.
Professional Isles was under contract with
Glasgow Warriors of the
Pro12. In February 2014, he signed to play with
Glasgow Warriors. He was a part of the Warriors 7's side that won the
Melrose Sevens in April 2014. Isles did not make an appearance for Glasgow Warriors first XV that season but gained experience playing 15's with the Scottish Premiership side
Ayr RFC, an amateur club in the Warriors district. At the end of the season Isles decided to leave the club and concentrate on playing rugby sevens in the
2016 Olympics. Isles was the leading try-scorer for the U.S. at that tournament. ==NFL career==