Smith has appeared in numerous films, including
The Moderns (1988),
The Silence of the Lambs (1991),
The Night We Never Met (1993),
Mr. Wonderful (1993),
Vanya on 42nd Street (1994),
Last Summer in the Hamptons (1995),
Trees Lounge (1996),
Kansas City (1996),
The Broken Giant (1997),
Random Hearts (1999),
Series 7: The Contenders (2001),
Bad Company (2002),
Melinda and Melinda (2004),
Iron Jawed Angels (2004),
Shooting Vegetarians (2005),
In Her Shoes (2005),
The Namesake (2006), and
Interstellar (2014). She appeared as a guest star on the sixth season of
Crossing Jordan as Dr. Kate Switzer, as one of
Claire Fisher's art teachers on
Six Feet Under, and on
Weeds as the ex-wife of Peter Scottson, the late husband of main character
Nancy Botwin. Smith originated the role of Andrea in the pilot of the
ABC drama series
Dirty Sexy Money, but was replaced by
Sheryl Lee after becoming a series regular on ''
Grey's Anatomy. On November 3, 2008, Smith told Entertainment Weekly that her character was being written out of Grey's Anatomy'', stating that she was "really, really shocked," and suggested that network executives' discomfort with her character's
lesbian relationship might be the reason for her ousting. However,
Shonda Rhimes, the show's creator, said that Smith was dismissed from the series because the writers did not find that the "magic and chemistry" that Smith's character had with
Sara Ramirez's character,
Callie Torres, would sustain in the long run. Smith has also had roles on
Homicide: Life on the Street,
Law & Order: Special Victims Unit,
Law & Order: Criminal Intent,
Law & Order,
Criminal Minds,
The Good Doctor and
The Hunger. In 2012, Smith also appeared in the
American Horror Story: Asylum episode "
The Coat Hanger". In 2015, she appeared as Frances Simpson on the
Showtime drama series
Ray Donovan. In 2016, Smith appeared in the recurring role of Sheriff Jane Greene in the fifth and final season of
A&E's
Bates Motel, a prequel series to director
Alfred Hitchcock's 1960 horror classic
Psycho. In 2019, Smith portrayed Dara, a counselor assigned to a young rape victim, in Episode 7 of
Unbelievable. It was released on September 13 on
Netflix. In 2020, she began a recurring role on the ABC series
Big Sky. In 2022, she released a photography book based on pictures she took of her friends in the Manhattan hardcore punk scene. ==Advocacy==