Main •
Jill Hennessy portrays Dr. Jordan Cavanaugh: A forensic pathologist in the Boston Medical Examiner's Office obsessed with solving violent crimes after her mother's murder. •
Miguel Ferrer portrays Dr. Garret Macy: The Chief Medical Examiner and Jordan's boss who deals with her erratic behavior as well as his own confused family. •
Ken Howard portrays Maximilian "Max" Cavanaugh: An ex-cop-turned-bar-owner and Jordan's father. •
Mahershala Ali (billed as Mahershalalhashbaz Ali) portrays Dr. Trey Sanders: A medical examiner working on a grant. •
Ravi Kapoor portrays Dr. "Bug" Vijay (born Mahesh Vijayaraghavensatyanaryanamurthy): A shy but intense
forensic entomologist. •
Kathryn Hahn portrays Lily Lebowski: A perky intake secretary and later grief counselor. •
Steve Valentine portrays Nigel Townsend: A wise-cracking British forensic technician and self-styled
criminologist. •
Lorraine Toussaint portrays Dr. Elaine Duchamps: An initially antagonistic medical examiner. •
Ivan Sergei portrays Dr. Peter Winslow: A medical examiner and recovering drug addict. •
Jerry O'Connell portrays Woodrow "Woody" Hoyt: A quirky Boston Police Department homicide detective, transplanted from
Wisconsin, who works regularly with Jordan. •
Leslie Bibb portrays Tallulah "Lu" Simmons: A Boston Police Department psychologist and homicide detective romantically involved with Woody.
Medical Examiners •
Jennifer Finnigan portrays Dr. Devan Maguire: A pathology resident who occasionally butts heads with Jordan. •
Eugene Byrd portrays Dr. Sidney Trumaine: An eager-to-prove-himself medical examiner. •
Brooke Smith portrays Dr. Kate Switzer: A cantankerous medical examiner assigned to the Medical Examiner's Office by Lu.
Boston Police Department •
D. W. Moffett portrays Eddie Winslow: A dismissive homicide detective and Max Cavanaugh's final partner. •
Amy Aquino portrays Lois Carver: A no-nonsense homicide detective. •
David Monahan portrays Matt Seely: A misogynistic and insensitive detective. •
Arija Bareikis portrays Annie Capra: A homicide detective briefly partnered with Woody. •
Sandra Bernhard portrays Roz Framus: A homicide detective with a tendency to tease Dr. Vijay. •
Camille Guaty portrays Luisa Santana: A homicide detective partnered with Woody on two cases. •
Boris Kodjoe portrays Elliot Chandler: A homicide detective who worked with the Medical Examiner's Office on two occasions.
District Attorneys •
Susan Gibney portrays Renee Walcott: A no-nonsense attorney romantically involved with Garrett. •
Brian Stokes Mitchell portrays Jay Myers: An attorney who has a sexual encounter with Jordan. •
Ethan Sandler portrays Jeffrey Brandau: An assistant district attorney who becomes romantically involved with Lily and becomes the father of her daughter. •
Jeffrey Donovan portrays William Ivers: An attorney who drastically lowers the budget of the Medical Examiner's Office.
Civilians •
Wallace Shawn portrays Dr. Howard Stiles: The Medical Examiner's Office's resident psychiatrist. •
Emy Coligado portrays Emmy: An assistant in the Medical Examiner's Office. •
Alex McKenna portrays Abby Macy: Dr. Macy's estranged daughter. •
Lindsay Frost portrays Maggie Macy: Dr. Macy's ex-wife. • Jack Laufer portrays Herman Redding: A psychiatric patient and murder suspect who claims to have knowledge about the death of Jordan's mother. •
Michael T. Weiss portrays James Horton: Jordan's illegitimate half-brother. •
Lesley Ann Warren portrays Arlene Lebowski: Lily's estranged aunt and adoptive mother. • Brian Kimmet portrays Oliver Titleman: A young student obsessed with creating the perfect crime. •
Charles Mesure portrays J.D. Pollack: An Australian reporter romantically involved with Jordan. ==Production==