The Battle of Chalk Bluff, also known as the Skirmish at Chalk Bluff, was a military engagement of the American Civil War. The battle was fought near Chalk Bluff, northwest of St. Francis, where U.S. Brigadier General William Vandever, commanding the Second Division of the Army of the Frontier, was repulsed in an attempt to prevent Confederate General John S. Marmaduke's Division from crossing the St. Francis River. Though a Confederate victory, Marmaduke suffered considerable casualties and his momentum had been checked, forcing him to abandon his second expedition into Missouri.