Olympiacos Lykogiannis is a product of the
youth system of
Olympiacos and soon became an important part of Olympiacos' football academy. He is considered as a most gifted players of his generation. On 25 January 2012, he made his debut with the first team in a
Greek Football Cup match against
Panionios as a substitute in the 82nd minute in front of 15,000 fans. On 25 October 2012, Lykogiannis made his European debut in an away
UEFA Champions League game against
Montpellier HSC as a substitute in the 88th minute. He was brought on to play as a defensive midfielder for the remaining minutes of the match. Four days after his debut in
UEFA Champions League, on 29 October 2012, Lykogiannis made his first appearance in an away game for
Super League Greece against
Aris as a substitute in the 68th minute. He signed a professional contract with Olympiacos in June 2011, which in August 2012 he renewed until summer 2015. In August 2013, he joined
Levadiakos on loan. A year later, in August 2014 he joined
Ergotelis on loan.
Sturm Graz On 16 July 2015, Lykogiannis joined
Sturm Graz for an undisclosed fee, having signed a contract for two years plus the option of a further year, while
Olympiacos kept a 30% future resale rate. On 6 August 2015, he made his debut with the club as a substitute in an away 1–1 draw against
Rubin Kazan for the 2nd leg of the 3rd qualifying
UEFA Europa League round. On 27 October 2015, he made his debut in the
Austrian Cup playing in a 3–2 win against ASK Ebreichsdorf. On 22 November 2015, he scored his first goal with the club in a 3–1 away loss against
Red Bull Salzburg for
Austrian Bundesliga. On 27 November 2016, he opened the score with a free kick, in a 2–1 away win against rivals
Rapid Wien. On 4 December 2016, he scored his second goal with another free kick in a 4–0 away win against
Wolfsberger AC. On 12 March 2017, Lykogiannis scored with a long distance kick after an assist from
Barış Atik giving a lead of two goals in his club in a final 2–1 home win against Rapid Wien. On 29 May 2017, Lykogiannis received a great distinction as he included in the team of the season for the
2016–17 season. Lykogiannis scored three goals and an equal number of assists in 36 games in all competitions. On 6 August 2017, he scored his first goal for the
2017–18 season in a 3–2 away win against
SV Mattersburg. On 25 November 2017, he scored the only goal with a wonderful kick after a corner from his teammate
Peter Žulj, in the extra time of the game sealing a 1–0 home win against
LASK Linz. In December 2017, it was reported that Lykogiannis’ performances had attracted interest from Greek clubs as well as foreign clubs like English Championship side
Leeds United. Eventually, he left the club having 81 appearances (6 goals, 5 assists) in all competitions. On 28 December 2019, Sturm Graz revealed their Team of the Decade, with
Tasos Avlonitis and Lykogiannis both included in the starting 11.
Cagliari On 17 January 2018,
Serie A Club
Cagliari managed to sign the Greek international, on a -year contract, for a transfer fee of €600,000. His contract, which ran until 2022, was worth €1.4 million per year. On 25 October 2020, he scored with a free kick in a 4–2 home win game against
F.C. Crotone. It was his first goal with the club in all competitions. During the
2020–21 season, Cagliari was in danger of being relegated this year. On 25 April 2021, Lykogiannis opened the score in a thrilling 3–2 win against
A.S. Roma and two weeks later scored a fantastic goal in the 1st minute of the match in a crucial game against
Benevento, where Cagliari prevailed 3–1. It was his best season so far, and his effectiveness can be seen from the statistics as he had 4 goals and 2 assists during 2020–21 season. The most important thing, however, is that the four times he sent the ball into the net, he scored his team's first goal in three wins and one draw.
Bologna On 1 July 2022, Lykogiannis moved to
Bologna. ==International career==