•
Charles Thompson (Cherokee chief) (died 1891), (Cherokee name
Oochalata), Principal Chief of the Cherokee Nation •
Charles Collins Thompson (1898–1983), Texas judge, attorney, banker and rancher •
Charles E. Thompson (1889–1986), member of the Mississippi Senate •
Charles Edwin Thompson (1890–1966), Canadian politician •
Charles H. Thompson (Florida politician) (1843 - ?), Baptist minister and state legislator for Columbia County 1873-1875, also a county commissioner •
Charles H. Thompson (Wisconsin official) (1935–2012), Secretary of the Wisconsin Department of Transportation 1987–1991 •
Charles H. Thompson (Illinois judge) (1882–1972), Chief Justice of the Illinois Supreme Court in 1945, 1946, 1949, and 1950 •
Charles J. Thompson (1862–1932), US Representative from Ohio •
Charles Perkins Thompson (1827–1894), US Representative from Massachusetts •
Tommy Thompson (Royal Navy officer) (Charles Ralfe Thompson, 1894–1966), British naval officer and Prime Ministerial aide-de-camp •
Charles Winston Thompson (1860–1904), US Representative from Alabama •
Charles W. Thompson (Kansas politician) (1867–1950), Lieutenant Governor of Kansas •
Mike Thompson (California politician) (Charles Michael Thompson, born 1951), US representative from California ==Religion==