Cosenza A versatile midfielder, Manfredini is a product of the
Juventus youth system and spent the early years of his career sent on loan by Juve to smaller clubs. Manfredini spent four seasons with different sides, playing in both
Serie C1 and
C2 until he was sent to
Cosenza in 1998 where he made his debut in
Serie B at the age of 23.
Genoa In 1999, after a year with Cosenza, Manfredini joined
Genoa, for 700 million lire or €361,520 (50% rights), also in
Serie B at the time. After just a season with Genoa, Manfredini then joined a club which was making its way forward on the Italian football scene. Genoa bought the residual rights from Juventus for 600 million lire and resold Manfredini in the summer 2000.
Chievo In 2000, Manfredini joined
Chievo, and was an important part of the first ever Chievo side to reach
Serie A, along with
Eriberto formed the "back arrow" as both wings. The team continued to surprise as they found themselves top of Serie A, eventually finishing fifth and achieving a
UEFA Cup place.
Lazio Manfredini did not stay any longer though as he had caught the eye of giants
Lazio, who he joined in 2002 in a
co-ownership deal for €6.715 million or 13 billion lire (10 billion lire cash (€5.165 million cash) plus half of the registration rights of
Pesaresi tagged for €1.549 million or 3 billion lire). Lazio later write-down the value of Manfredini to €2.3 million, after both club withdrew the remain 50% registration rights. At first, Manfredini failed to break into the strong Lazio side and was sent on loan to
Osasuna in Spain, as well as
Perugia and
Fiorentina. In 2004, Lazio went into a financial meltdown and were forced to sell many of their top players. Manfredini was recalled to the team and while not always a regular in the first eleven, made many appearances for the capital club. Manfredini also scored a goal in the
UEFA Champions League against German side
SV Werder Bremen. Manfredini did not play any game in
2009–10 Serie A and
2010–11 Serie A. His contract was extended 5-year on 1 July 2006. His contract with Lazio expired in June 2011 and was not renewed.
Sambonifacese He has signed with
AC Sambonifacese on 16 July 2011 and has played 11 games in the season 2011–12.
Agropoli In the season 2012–13 he played for newly promoted in
Serie D.
Picciola In the season 2013-2014 he played for
Picciola. ==International career==