After leaving school, Lorre toured the United States as a guitarist and songwriter. He wrote the song "
French Kissin", which
Deborah Harry later recorded for her 1986
Rockbird album He co-wrote the soundtrack to the 1987 television series
Teenage Mutant Ninja Turtles with
Dennis Challen Brown. Lorre rejected an invitation from
DIC Animation City to be story editor for
The New Adventures of Beany and Cecil, only to accept the offer as animation writers were not affected by the
1988 Writers Guild of America strike, which put him out of work, while also being contracted to compose stock music for the series. Despite gaining support from
ABC, he was immediately shunned by developer
John Kricfalusi and practically everyone else involved for the quality of his work and lack of passion. He was fired after an argument with original creator
Bob Clampett's widow and son on this matter for this regard after complaints by other crew members. In the late 1980s, he shifted into writing for sitcoms, and joined the writing staff of
Roseanne. Though he was fired over "irreconcilable creative differences", Lorre's time on
Roseanne impressed producers, and led to his creating his first show, ''
Frannie's Turn''. It was cancelled after 5 weeks. Lorre's second show as creator,
Grace Under Fire, starred comedian
Brett Butler. Lorre then moved to 20th Century Fox in 1995, creating
Dharma & Greg in partnership with
Dottie Zicklin (credited as Dottie Dartland), which premiered one year before the end of
Cybill in 1997. The show received eight Golden Globe nominations, six Emmy Award nominations, and six Satellite Awards nominations, and Elfman won a Golden Globe for Best Actress in 1999. Lorre created his fifth show,
Two and a Half Men, with co-creator
Lee Aronsohn. It focuses on the two Harper brothers,
Charlie and
Alan. Charlie is a hedonistic, successful commercial jingles composer and womanizer who owns a beach house in
Malibu. Alan is a neurotic chiropractor, thrown out of his own house by his divorcing wife. The premise is that Alan worms himself into Charlie's house and clashes with his lifestyle. Alan also has a son, Jake, the "half", who comes to visit him and Charlie on weekends.
Two and a Half Men premiered on CBS in 2003 and became the highest-rated sitcom in America. Sheen was fired from the show and then filed a $100 million lawsuit against Lorre and
Warner Bros. Television for wrongful termination. Lorre killed off Sheen's character and hired
Ashton Kutcher as his replacement for the show's later four seasons. Lorre's next show was
The Big Bang Theory with co-creator
Bill Prady. It follows two genius physicists,
Sheldon Cooper and
Leonard Hofstadter, with few social skills who befriend their neighbor, an attractive, outgoing young woman with average intelligence and no college education. The episodes usually focus primarily on the daily lives of the men and two of their brilliant but equally socially challenged friends, with a dose of absurdity from the relationship with their less educated but socially astute neighbor. The two main protagonists are named after actor and
television producer Sheldon Leonard. The show was broadcast on CBS from 2007 to 2019 and was the highest rated comedy series in the United States.
Other shows Lorre was executive producer of
Mike & Molly, created by
Mark Roberts, which premiered on CBS in September 2010. His seventh show, created with Gemma Baker and
Eddie Gorodetsky,
Mom, premiered on CBS on September 23, 2013. On March 13, 2014, CBS announced the second season renewal of
Mom. It ran for eight seasons. Controversy surrounded
United States of Al, a show produced by Lorre for
CBS. Released to mostly negative reviews,
United States of Al and its makers were criticized for the show's humor, use of antiquated tropes, and in particular, the casting of a South-African-born Indian actor to play an Afghan lead and his use of an inauthentic accent. ==Vanity cards==