John DeWitt, a New York merchant, hired Lewis in 1851 to assist DeWitt's son-in-law, Lucius Allen, in running a wholesale supply house in Portland, a frontier settlement on the West Coast. Portland, with a population of about 800, was in good position to trade via the
Willamette and
Columbia rivers and the Pacific Ocean with
San Francisco and other ports and by land with an increasing number of pioneer farmers in the
Willamette Valley. Allen, a friend of Lewis, had tried and failed in 1850 to establish a Portland branch store, and DeWitt thought that the more experienced Lewis would be able to help. In 1883 after several setbacks, the two men opened their own business (independent of New York) in a rented store at Front and "B" (Burnside) streets. They specialized in dry goods and groceries, building customer loyalty by selling at a fixed price, extending credit to reliable customers, and offering free space in their safe for storage of their customers' gold. became "merchant princes of the Northwest". In 1891, Lewis was named to the original
Port of Portland Commission, established by the
Oregon Legislative Assembly to oversee the maritime commercial and shipping interests of the city. When railroads began replacing steamships as a shipping method in the 1870s, Lewis, Ladd, Corbett, Failing, and
Simeon Reed (a Portland transportation executive), became the five largest stockholders, aside from
Henry Villard, in Villard's
Oregon Railway and Navigation Company (OR&N). In 1888, Lewis was part of a group that visited Villard in New York to negotiate favorable shipping rates on the
Union Pacific and the
Northern Pacific railroads, with which Villard and the OR&N had contracts affecting Portland. Lewis's interest in Portland railroads extended to the
Portland & Willamette Valley Railroad, of which he became a local director in 1885, and which was controlled and formally taken over by the
Southern Pacific Railroad in 1890. Lewis and the other three pioneer merchants were among those in 1864 who formed the Mercantile Library Association (later renamed the Library Association of Portland) to establish a local
subscription library. Roughly 30 years later, after a public library opened in Portland in 1891, members of the Cicero Lewis family were among its largest donors. In 1885, Lewis was one of 15 men named to the
Portland Water Committee, empowered by the state legislature to acquire and operate a municipal water system for the city. ==Family, other interests, death==