Fifth civil war When Anjou returned to France as Henri III, he was confronted with civil war. La Guiche served the royalist cause through his command of an ordinance company during 1575. Henri was looking to counter the influence of
the duke of Guise over the army. Guise was colonel-general of the light cavalry at the time. To dilute his influence over the important command, La Guiche was established by the king as
maître de camp for the light cavalry, succeeding
Jean de La Valette in the role. La Guiche was also established as a
gentilhomme de la chambre du roi in that year.
Sixth civil war During the sixth civil war, he fought around the Protestant held town of
Brouage on the Atlantic seaboard, alongside
Caylus, another favourite of the king. The two men were captured by the Protestants in July at
Saugeon, much to the king's frustration. The capture was planned by the Protestant governor of
Royan, Campeste. Caylus and La Guiche appeal to another favourite of the king
Beauvais-Nangis to negotiate their release. They would however only be released with the signing of peace three months later. On 6 July 1578, La Guiche traded his responsibilities as
Maître de camp for the light horse to
Saint-Mégrin. In return for yielding this charge to another favourite of the kings, La Guiche was granted the role of ''Grand Maître de l'artillerie
. A member of the conseil d'État'', La Guiche's presence was infrequent.
King of Nederland As a result of his proximity to the king's brother
Alençon he was among the many nobles who assembled at
Château-Thierry in May 1581 to accompany Alençon on his campaign into Nederland. Alongside him were
the duke of Elbeuf of the powerful Lorraine family,
Saint-Luc the disgraced royal favourite and the Protestant
Turenne.
Catherine de Medici fruitlessly tried to appeal to her son to reconsider his expedition, however he rebuffed her attempts. The army moved to
Cambrai where it relieved the city from the Spanish siege it was subject to.
Épernon During the 1580s,
Épernon moved into ascendency at court as one of the kings two chief favourites. As such he was in a position to make many requests of the king for his clients. Sensitive to the position of the leading military men, La Guiche and
Joachim de Châteauvieux he made sure that the requests he made did not impinge upon their positions. Épernon was very close to La Guiche, considering him one of the few men in which he could confide. In February 1586 when planning his return to court, it was to La Guiche he wrote to ensure that the road would be safely filled with his allies. This meant that when Épernon conducted campaigns against the Protestants in 1586, in
Dauphiné and
Provence, La Guiche was a participant in the campaign. At council in October 1587, Épernon, favourite of the king, denounced one of Henri's chief ministers
Villeroy. He accused Villeroy of corruption as concerned state funds. La Guiche who was present intervened, trying to calm Épernon, who was threatening to assault Villeroy. A confrontation was averted. After the
assassination of the duke of Guise in December 1588, Henri, increasingly insecure about who he could trust, reformed his council again. La Guiche was among those men who maintained their position in his new council for 1589. Alongside him were
Marshal Retz,
Claude d'Angennes,
Maintenon,
Rambouillet and
François d'O. ==Reign of Henri IV==