Oosthuizen went to Laerskool Gustav Preller in Roodepoort for his primary education and attended
Grey College in Bloemfontein. Oosthuizen plays in the loose-head prop position, although he can play both sides of the scrum. He boasts surprising pace for a man of his colossal weight (127 kg). He ended the 2010 Currie Cup season as the Cheetahs top try scorer. Oosthuizen is known for his strong runs and work rate around the pitch but has often struggled in the scrum against the more technical scrummagers. In 2010 Coenie scored a
hat trick of tries for the
Free State Cheetahs in a
Currie Cup game against the neighbouring
Griquas team. It is after a stand-out season for the Cheetahs during the 2010
Currie Cup domestic rugby season that Coenie was selected as part of the Springbok squad for the November 2010 tour of Europe. Oosthuizen made his first test appearance on 9 June 2012 against
England in
Durban. On 13 May 2019, it was announced that he had signed a 3-year deal with
Sale Sharks, and would join them after the conclusion of the
2019 Super Rugby season. In 2016, Oosthuizen was included in a
South Africa 'A' squad that played a
two-match series against a touring
England Saxons team. He came on as a replacement in their first match in
Bloemfontein, but ended on the losing side as the visitors ran out 32–24 winners. He also played off the bench in the second match of the series, a 26–29 defeat to the Saxons in
George.
International tries ==Squads==