Contralateral brain

Anatomically, the contralateral organization is manifested by major decussations (based on the Latin notation for ten, 'deca,' as an uppercase 'X') and chiasmas (after the Greek uppercase letter 'Χ,' chi). A decussation denotes a crossing of bundles of axonal fibres inside the central nervous system. Due to decussations the efferent connections of the cerebrum to the basal ganglia, the cerebellum and the spine are crossed; and the afferent connections from the spine, the cerebellum and the pons to the thalamus are crossed. Thus, motor, somatosensory, auditory, and visual primary regions in the forebrain predominantly represent the contralateral side of the body. Two of the cranial nerves show chiasmas: (1) the chiasma of the optic tract (i.e., cranial nerve II), which originates from the eyes and inserts on the optic tectum of the midbrain; and (2) the trochlear nerve (i.e., cranial nerve IV), which originates in the ventral midbrain and innervates one of the six muscles that rotate the eye (i.e., the superior oblique muscle). The oculomotor nerve (cranial nerve III) crosses the midline before leaving the central nervous system (i.e. it decussates rather than chiasmates). The contralateral organization is incomplete Although the forebrain of all vertebrates shows a contralateral organization, this contralaterality is by no means complete. Some of these exceptions are worth mentioning: • Olfaction (i.e., smelling sense) is a noteworthy exception. Each olfactory lobe connects to the ipsilateral (same-side) centers of the frontal cerebrum. • In large brains (e.g., humans, elephants and whales), some functions tend to be strongly lateralized. For example, the language regions (i.e., Broca's and Wernicke's area) are situated in the left hemisphere of most humans. • Most afferent and efferent connections of the forebrain have bilateral components, especially outside the primary sensory and motor regions. As a result, a hemiplegia that is acquired at very young age can sometimes be completely compensated over time. == Theories ==

According to current understanding, the contralateral organization is due to an axial twist (explained below). A number of other explanations have been published, the most popular of which is the visual map theory (explained below). A short review of existing hypotheses is given by reference. A popular-science video explains these theories in brief. The Visual Map Theory and the Axial Twist Theory have been formulated in detail and can be regarded as scientific theories, and are explained in detail below. Other hypotheses tend to explain specific aspects of the phenomenon. One proposes that crossing generally provides better geometrical mapping. According to another view, the crossing is a coincidence that has been conserved by parcellation. An old notion, first worked out by Jacques Loeb, is that the contralateral organisation might have an advantage for motor control, but simulations by Valentino Braitenberg have shown that both ipsi- and contralateral connections are of major importance for control. Further studies have asked if there is a topological or functional advantage of the decussations. Visual map theory The visual map theory was published by the famous neuroscientist and pioneer Santiago Ramón y Cajal (1898). According to this theory, the function of the optic chiasm is to repair the retinal field image on the visual cortex. The pupil in the vertebrates' eyes inverts the image on the retina, so that the visual periphery projects to the medial side of the retina. By the chiasmatic crossing, the visual periphery is again on the outside, if one assumes that the retinal map is faithfully maintained throughout the optic tract. The theory has a number of weaknesses. For example, the visual tracts spiral their way from the thalamic LGN to the visual cortex. (See figure; this path is known as the optic radiation.) As a result, the retinal map shows the visual periphery on the medial side. However, the central objective of the theory was to obtain a precise, faithful visual map with the medial field projecting to the medial sides of the visual cortex. Both of them propose that the rostral part of the head, including the forebrain, is in fact effectively completely turned around. As a consequence, the left and right in the brain are reversed, but also anterior (frontal) and posterior (back / occipital). Axial twist theory The axial twist theory was designed to explain how the pattern of contralateral organization, having no known exceptions throughout the 500 million years of vertebrate evolution. According to the theory, the contralateral organization develops as follows: The early embryo is turned onto its left side, such that its left is turned to the yolk and its right is turned away from the yolk. This asymmetric orientation is compensated by asymmetric growth, to regain superficial bilateral symmetry. The anterior head region turns to the left, as shown in the schema. The forebrain is not a superficial structure, but it is so intimately associated with superficial body structures that it turns along with the anterior head. These structures will later form the eyes, nostrils and mouth. and was proposed by Marcel Kinsbourne. According to the dorsoventral inversion hypothesis, an ancestral deuterostome turned on its back. As a result, vertebrates have a dorsal nervous system, whereas protostomes have a ventral one. According to the somatic twist hypothesis, not the entire animal turned on its back but just the somatic part—i.e., everything behind the eyes, mouth and nostrils, including the forebrain. The somatic twist hypothesis was proposed as an improvement to the inversion hypothesis, and thus has a much wider explanatory power than its predecessor, but is also more complicated. It not only explains the inversion of the body but additionally the contralateral forebrain. It does not explain, however, how the twist might develop in the vertebrate embryo, nor does it address the possible evolution. The axial twist theory was proposed independently. In addition to providing rationale for the inverted body and the contralateral forebrain, it explains why the heart and bowels are asymmetric. It is the only one of the three theories that is supported by evidence from embryological growth. == Evolution ==

A remarkable property of the contralateral organization is that it is present in every vertebrate. Even the most distant clades—agnathans—possess an optic chiasma, this idea was worked out by Kinsbourne. It is not known, however, what exactly was the selective pressure that caused the inversion. Twisting and asymmetric development are well known from other deuterostomes—such as Hemichordata, Echinodermata, Cephalochordata and Tunicata. Turning toward the side or upside-down also occurs frequently in these clades (e.g. sea stars which turn their mouth downwards after the larva has briefly settled with the mouth turned up, or the adult lancelet which buries obliquely with its mouth turned up, or many fish which tend to turn around when feeding from the water surface). == Developmental malformations ==

In holoprosencephaly, the hemispheres of the cerebrum or part of it are not aligned on the left and right side but only on the frontal and occipital sides of the skull, and the head usually remains very small. According to the axial twist hypothesis, this represents an extreme case of Yakovlevian torque, and may occur when the cerebrum does not turn during early embryology. Cephalopagus or janiceps twins are conjoined twins who are born with two faces, one on either side of the head. These twins have two brains and two spinal cords, but these are located on the left and the right side of the body. According to the axial twist hypothesis, the two nervous systems could not turn due to the complex configuration of the body and therefore remained on either side. == See also ==