This line was opened by the
North Staffordshire Railway Company and became part of the
London Midland and Scottish Railway in 1923. The line was opened between and on 7 August 1848. The next stage from there to was opened 11 September 1848. Just beyond Tutbury was formerly a branch line to , having opened on the same date, but is now closed. A separate company, the Cheadle Railway Company, built a line from to , which was opened throughout on 1 January 1901 and was closed to passengers in 1953 and to freight traffic in 1978. The section of line between and the
Midland Railway's to line was opened on 13 July 1849. The section between Stoke and is part of the
West Coast Main Line which, together with the section from Kidsgrove to Crewe, opened on 9 October 1848. By the 1980s, the Crewe-Derby service was operated by
British Rail's
Regional Railways sector, with services continuing to then either , or . When
Central Trains was awarded the franchise for the line in the 1990s, it was expanded to run between and Skegness. However, poor punctuality meant that this was later curtailed to Crewe-Skegness. In autumn 2005, further poor performance saw the through service limited to Crewe-Derby. During 2003, much of the line was closed as part of the West Coast Main Line upgrade, with trains terminating at and a shuttle bus service running between there and Crewe. After the closure, all stations on the route reopened, except which was closed in 2005. As a result of the upgrade, the section from Crewe to Kidsgrove was
electrified for use as a diversionary route for the West Coast Main Line. In May 2021, services provided by
East Midlands Railway were extended to provide Crewe and Stoke-on-Trent, with direct links past Derby to Nottingham and . The service is still run hourly and journeys between Stoke-on-Trent and Nottingham take approximately 90 minutes. In December 2025 the timetable was revised and services were extended beyond Newark Castle to Lincoln. ==Route==