Billy was born in
Florida to
Curt and
Martha Connors, the former of whom is a biologist. The family move to
New York City so that Curt can continue his research in limb regrowth. Curt's research leads him to transform himself into a reptilian creature called the Lizard, who attempts to kill Billy. Billy is rescued by
Spider-Man, who returns Curt to normal with an antidote to the Lizard formula. Martha and Billy are kidnapped by a branch of the
Maggia led by
Silvermane, who intends for Curt to decipher an ancient tablet. Spider-Man and the
Human Torch save Martha and Billy, who are happily reunited with Curt. Curt eventually chooses to leave his family, saddening Billy and Martha. Curt later returns and turns Billy into another lizard creature dubbed
Lizard Jr., but the two are captured and returned to normal by Spider-Man. Sometime later, Martha and Billy contract cancer after being exposed to
carcinogenic chemicals. Martha dies, while Billy survives and is forced to live with his aunt. During the storyline
The Gauntlet and Grim Hunt, Curt loses custody of Billy, who the Lizard kills in an attempt to suppress Curt's personality. In the
Dead No More: The Clone Conspiracy storyline,
Ben Reilly resurrects Billy and Martha in clone bodies to motivate Curt to work for him. The two are later infected with the
Carrion virus, which threatens to degrade their bodies. Curt injects them with his Lizard formula, transforming them into reptilian creatures like himself, to save their lives. During the
Hunted storyline, Billy is captured and used as a hostage by
Kraven the Hunter as part of Kraven's efforts to test his clone, the
Last Son of Kraven, and provoke Spider-Man into becoming the "hunter" Kraven feels his enemy should be. When trapped in a cage with Curt, Spider-Man learns that Curt took Billy to
Doctor Strange after his resurrection. Strange confirmed that the resurrected Billy is the original Billy's soul reborn in a cloned body rather than a separate individual. An amnesiac Billy appears as a member of Squid Kid's
Sinister Six as Lizard Boy. He and Martha are later recruited into the
Sewer Enclave by
Miles Morales' clone
Shift. ==Other versions==