Main • Dan (voiced by
Curtis Armstrong) is the main protagonist of the series. He is a very temperamental young man with extreme anger issues. In every episode, he plots revenge against anyone or anything which has enraged him with the help of his best friend Chris. • Chris (voiced by
Dave Foley) is Dan's best friend and Elise's husband. He often gets dragged into Dan's schemes as his semi-reluctant accomplice, much to his dismay. • Elise (voiced by
Paget Brewster) is Chris' more levelheaded wife, who strongly dislikes Dan due to his rude and immature personality. She is also a spy working for an unnamed "quasi-governmental" secret organization.
Supporting • Mr. Mumbles (vocals by
Paget Brewster) is Dan's pet cat who is rescued in the episode "The Animal Shelter". Despite the name, Mr. Mumbles is actually female as it’s implied Dan never bothered to check. • Crunchy (voiced by
Tom Kenny) is a happy-go-lucky, dreadlock-wearing
hippie who works at several jobs throughout the series. His workplaces are often the target of Dan’s hijinks. • Sheriff (voiced by
John DiMaggio) is a large, fat, tough police man who is seen every time Dan makes reports. Whenever Dan makes trouble, the sheriff uses a
taser to shock him. • Don (voiced by
Michael Gross) is Elise's father who runs a successful cupcake store chain and hates Chris, to the point of trying to convince Elise to marry another man by various means (usually at Chris's expense). • Elise Sr. (voiced by
Meredith Baxter) is Elise's mother. She dislikes Chris, (but not quite as much as her husband) and she keeps her time and attention to an unspecified Mafia family, unbeknownst to her husband and daughter. • Ninja Dave (voiced by
Eric Bauza) is a former ninja of the Koshugi clan who swore never to bake cookies, thus had to steal them whenever he wanted to eat some and to destroy any rivals of his clan. • Spy Boss (voiced by Dan Mandel) is the unnamed and unseen boss of Elise who sends her on different missions during specific episodes. It is revealed he is a former super model in the episode "The Common Cold". • Hortence (voiced by
Grey DeLisle) is an airhead employee of the Burgerphile restaurant chain who falls for Dan after he begins a protest against the restaurant. • The Imposter (voiced by
John C. McGinley) is an unnamed man who steals Dan’s identity and impersonates him. He manipulates everyone around him and portrays himself as a "good neighbor" to steal Dan's life. He is later arrested for Dan’s failure to serve jury duty, and swears revenge. He later returns in "The Telemarketer" where he continually harasses Dan with phone calls, and eventually gets Dan arrested. • Ben (voiced by Eric Bauza) is Elise's younger brother and Chris' brother-in-law who was mentioned in the episodes "Elise's Parents" and "The Family Camping Trip" and appears in "The Family Thanksgiving" and "The Dinosaur". He seems to show a lack of distrust in Chris and has grown fond of him. • Mechanic Mike (voiced by
Kurtwood Smith) is Dan's local mechanic who works on his car
free of charge since he loves working on off-brand Filipino cars. == Voice actors ==