2C-TFM

A psychedelic dose of 2C-TFM has been reported by Daniel Trachsel and Alexander Shulgin to be 3 to 6mg orally. Its duration has been reported by Trachsel to be 5 to 7hours or 6 to 10hours or more in different publications. It is the most potent member of the 2C family. == Interactions ==

Pharmacodynamics The mechanism that produces the hallucinogenic and entheogenic effects of 2C-TFM is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines. 2C-TFM displaced radiolabelled ketanserin from 5-HT2A/C receptors with a Ki of 74.5 nM, as compared to a Ki of 80.9 nM for the more well known 5-HT2A agonist DOI, indicating similar binding affinity at the receptor. ==Chemistry==

2C-TFM is a code that represents 4-trifluoromethyl-2,5-dimethoxyphenethylamine. The full name of the chemical is 2-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]ethanamine. Synthesis The chemical synthesis of 2C-TFM has been described. Since 2C-TFM is usually synthesised from 2C-I and the reaction does not generally consume all of the starting material, samples of 2C-TFM are likely to be contaminated with detectable traces of unreacted 2C-I, which may pose legal issues in jurisdictions where 2C-I is illegal, even though 2C-TFM itself may not be prohibited. Analogues and derivatives Analogues and derivatives of 2C-TFM include 2C-TFE, 2C-T-TFM (2C-T-36; CYB210010), DOTFM, 4C-TFM, TFMFly (DOTFM-FLY), 25TFM-NBOMe, LPH-5 ((S)-2C-TFM-3PIP), and 2T-2CTFM-3PIP, among others. ==History==

2C-TFM was first described in the scientific literature by David E. Nichols and colleagues in 1994. ==Society and culture==

Legal status Canada As of October 31st, 2016, 2C-TFM is a controlled substance (Schedule III) in Canada. United States 2C-TFM is unscheduled and uncontrolled in the United States, but possession and sales of 2C-TFM could potentially be prosecuted under the Federal Analog Act if intended for human consumption because of its structural similarities to 2C-B and 2C-T-7. However, 2C-TFM, unlike many other phenethylamines, has not been widely sold by internet retailers. In the wake of Operation Web Tryp in July 2004, the issue of possession and sales of 2C-TFM and other similar chemicals will probably be resolved in the courtroom as well the fate of this rare but unique psychedelic. There have been no reported deaths or hospitalizations from 2C-TFM. == See also ==