Pre-draft Kizer received an invitation to the
NFL Combine and completed all of the combine drills except for the
bench press. He also performed positional drills, but had a disappointing performance. Kizer also participated at Notre Dame's
Pro Day and only ran positional drills in front of team scouts and representatives, including
San Francisco 49ers general manager
John Lynch and
Pittsburgh Steelers offensive coordinator
Todd Haley. Kizer completed 50-of-60 passes and showed significantly better accuracy and footwork at his pro day.
Cleveland Browns The
Cleveland Browns selected Kizer in the second round (52nd overall) of the 2017 NFL draft. He was the fourth quarterback selected and first taken in the second round. On June 14, 2017, the Browns signed Kizer to a four-year, $4.94 million contract that includes $2.42 million guaranteed and a signing bonus of $1.73 million. On August 27, following the team's third preseason game, the Browns named Kizer as the starting quarterback to begin the regular season, beating out veteran trade acquisition
Brock Osweiler and second-year quarterbacks
Cody Kessler and
Kevin Hogan. Making his NFL debut on September 10, 2017, Kizer finished with 222 passing yards, a touchdown, and an interception to go along with 17 rushing yards and a one-yard touchdown, but the Browns lost by a score 21–18 at home to the Steelers. He orchestrated a 12-play drive that ended after scoring on a one-yard touchdown run. Kizer started the next four games for the Browns, which were all losses. During a Week 5 17–14 loss to the
New York Jets, Kizer was benched in favor of Kevin Hogan to begin the third quarter after throwing for 87 yards and an interception in the first half. Hogan was later named the starter for the team's Week 6 matchup against the
Houston Texans. After Hogan's struggles in Week 6, Kizer was renamed the starter for the Week 7. During a Week 7 12–9 overtime loss to the
Tennessee Titans, Kizer threw for 114 yards and two interceptions before being benched in favor of Cody Kessler in the third quarter. Following the game, reports surfaced that Kizer was out late the Friday before the game, which caused some controversy. During a Week 14 27–21 overtime loss the
Green Bay Packers, Kizer threw for 214 yards and a season-high three touchdowns, but also threw two interceptions, including one in overtime that gave the Packers excellent field position. In the regular-season finale against the Steelers, Kizer finished with a season-high 314 passing yards, two touchdowns, and an interception during the 28–24 road loss. The Browns finished the season with an 0–16 record, only the second team in NFL history to have that record. In 15 games and starts of his rookie season, Kizer completed 53.6 percent of his passes for 2,894 yards, 11 touchdowns, and a league-leading 22 interceptions to go along with 77 carries for 419 yards and five touchdowns.
Green Bay Packers On March 14, 2018, Kizer was traded to the Packers in exchange for
Damarious Randall and a swap of both fourth and fifth-round draft picks. During the season-opener against the
Chicago Bears, Kizer played in place of an injured
Aaron Rodgers in the first and second quarters, throwing for 55 yards and an interception, which was returned for a touchdown, while also losing a fumble after being strip-sacked. Rodgers returned in the third quarter and led the Packers to a narrow 24–23 comeback victory. In the regular-season finale against the
Detroit Lions, Kizer played in relief of Rodgers, who had suffered a concussion, and threw for 132 yards and an interception as the Packers were shut-out by a score of 31–0. On August 31, 2019, Kizer was released as part of the final roster cuts.
Oakland / Las Vegas Raiders On September 1, 2019, Kizer was claimed off waivers by the
Oakland Raiders. On May 5, 2020, Kizer was waived by the relocated
Las Vegas Raiders. He was re-signed to the
practice squad on September 7, and was released on September 30.
Tennessee Titans On November 24, 2020, Kizer was signed to the
Tennessee Titans practice squad. He was signed to a futures contract on January 11, 2021. Kizer entered the 2021 offseason as the third-string quarterback competing with backup
Logan Woodside for the No. 2 spot behind starter
Ryan Tannehill. Kizer was released on August 5, 2021, after the Titans signed quarterback
Matt Barkley. Kizer was re-signed to the practice squad on November 26, but was released three days later. ==Career statistics==