Pharmacodynamics In animal studies, desoxymethyltestosterone has been found to bind to the
androgen receptor (AR) about half as strongly as DHT, and to cause
side effects that are typical of 17α-alkylated AAS, such as
liver damage and
left ventricular hypertrophy when taken in higher doses. Desoxymethyltestosterone is unusual in that it is structurally a 2-
ene compound, lacking the 3-
keto group present in almost all commercial AAS (with
ethylestrenol being a rare and notable exception). This does not mean it is a weak compound, and clinical research has determined that it is a fairly potent oral agent. Because of this favorable ratio, experiments in
orchiectomized rats have demonstrated that treatment with desoxymethyltestosterone resulted only in a stimulation of the weight of the levator ani muscle; the
prostate and
seminal vesicle weights remained unaffected leading the authors of one study to characterize desoxymethyltestosterone as a powerful AAS with attributes of a
selective androgen receptor modulator (SARM) and some indication of
toxicity. ==Chemistry==