Janssen played for the first time for a Junior selection of
Royal Dutch Football Association on 17 March 2010 at the friendly match of U-15 national team against England. In 2012, she was captain of the Dutch U-17 team in the qualifying matches for the
2012 UEFA Women's Under-17 Championship and also led the team, as captain, in qualifying for the
2013 UEFA Women's Under-19 Championship. In 2014, she succeeded with her team to qualify for the final round the
2014 UEFA Women's Under-19 Championship in
Norway, where Netherlands won the title for the first time with 1–0 victory against Spain. Janssen played all five matches in the tournament. In 2014, she was called for the senior team for the first time, taking part in the
Netherlands squad for the
2014 Cyprus Cup. On 5 March 2014, she made her debut, coming off the bench in the 65th minute at 2–2 against
Australia. Janssen was then a part of the Dutch team that reached the
2015 World Cup Round of 16. Dominique was a member of the Netherlands team that won
Euro 2017 on home soil. Capturing the support of the entire nation,
Sarina Wiegman's side beat
Sweden and
England in the quarter-finals and semi-finals respectively without conceding a goal in order to reach the final against
Denmark. The Dutch won the final 4-2 to secure their very first
UEFA Women's Championship title and Janssen featured in the historic match when she replaced Desiree van Lunteren in the 57th minute as a substitute for the Oranje. After winning the 2017 European Championships, the whole team was honoured by the
Prime Minister Mark Rutte and
Minister of Sport Edith Schippers and they were made Knights of the
Order of Orange-Nassau. In 2019, she was included in the Dutch squad for the
2019 World Cup. The Netherlands won every group stage match and reached the final, eventually losing 2–0 to the
United States. Janssen played in all seven of the Leeuwinnen's games and didn't miss a single minute. In the second group game against
Cameroon, she scored her first international goal. In the subsequent
qualification for the 2022 European Championships, she played in nine out of ten games and scored one goal. With ten wins, the Dutch qualified for the finals, which were postponed by a year due to the COVID-19 pandemic. For the same reason, the
2020 Olympic Games, for which the Dutch had qualified for the first time as runners-up in the World Cup, were also postponed by one year. Janssen played in victories against
Zambia (10–3) and
China (8–2) as well as the 3–3 draw with
Brazil, where she scored the final goal to produce a 3–3 scoreline, before losing on penalties to the world champion U.S. team in the quarter-finals. In the
2023 World Cup qualification, she was used six times in the first seven games. On 31 May 2022, Janssen was nominated for the
European Championship finals and completed all four games of the Dutch team there. In the quarterfinals against
France, she committed a foul in extra-time which led to France's decisive penalty goal. On 31 May 2023, Janssen was named as part of the Netherlands provisional squad for the
2023 World Cup, and she featured for the team which reached the quarter-finals of the competition, before losing 2-1 after extra-time to eventual tournament winners
Spain. In November 2025, following the international retirement of
Sherida Spitse in the previous month, Janssen was announced as the new captain of the Dutch women's national team. Speaking about the appointment, she said: "I'm incredibly proud. I feel the trust from the staff, and I can't wait to take on this role. I won't change as a player. I just get to walk out first and do the toss, the rest stays the same."
International goals :
Scores and results list the Netherlands goal tally first. ==Personal life==