Preston has appeared in a number of films and television series. Film work includes
Set the Thames on Fire (starring
Noel Fielding),
Grimsby (starring
Sacha Baron Cohen), ''
The Hitman's Bodyguard (starring Ryan Reynolds and Samuel L. Jackson) and Holmes & Watson'' (starring
Will Ferrell and
John C. Reilly). She has also regularly lent her voice to the
Discovery Channel,
BBC,
ITV,
E4,
Amazon and
Channel 4. In 2018, she appeared in
Coronation Street,
Fantastic Beasts: The Crimes of Grindelwald, and took a lead role in ''
Michael McIntyre's Big Show'' executing pranks involving improvisation on the general public. In 2019, she appeared on
Pants on Fire on
E4. Preston wrote and co-produced the series
Fully Blown for BBC Three's Comedy Threesomes, transmitted in 2019, which was nominated for a Broadcast Digital Award 2020. From 2019 to 2020, Preston starred as Tracey in
Hey Tracey! on
ITV2, alongside
Joel Dommett, and appeared in episodes of
The Mash Report on
BBC Two. She has appeared in a number of online comedy sketches for Channel 4. In 2020, she appeared in episodes of
BBC Three's Famalam and the feature film
Loves Spell. That year she was also shortlisted for the
Funny Women Awards 2020, and was a guest on
8 Out of 10 Cats on Channel 4. In 2021, she guest starred on
Inside No. 9, and co-hosted ITV's
Apocalypse Wow!. She appeared as herself on Sky One's
Dating NoFilter,
CelebAbility, and
Strictly Come Dancing: It Takes Two. During the same year, she was nominated for two
Channel 4 National Comedy Awards, for Outstanding Female Comedy Entertainment Performance and the Comedy Breakthrough Award. In 2022, she appeared as
Despair in
The Sandman and as Pat in
Catherine Tate's six-part
mockumentary sitcom
Hard Cell, both released on
Netflix. In 2023, she played Mrs Sandwich in
Good Omens, alongside fellow
The Sandman cast member
Crystal Yu. In 2024, she reprised her role as Despair in
Dead Boy Detectives, and appeared in
Pickle Storm a new children's comedy drama on
CBBC. == Filmography ==