Cleveland Browns Peoples-Jones was selected by the
Cleveland Browns in the sixth round with the 187th overall pick of the 2020 NFL draft. He signed his rookie contract with the Browns on May 20, 2020. On October 25, 2020, Peoples-Jones caught three passes for 56 yards and the game-winning touchdown with 11 seconds left in the game during the 37–34 victory over the
Cincinnati Bengals in Week 7. In Week 13 against the
Tennessee Titans, Peoples-Jones recorded two catches for 92 yards, including a 75-yard touchdown, during the 41–35 win. In Week 14 against the
Baltimore Ravens, Peoples-Jones recorded three catches for 74 yards and a two-point conversion. He was placed on the reserve/
COVID-19 list by the team on December 26, 2020, and activated on December 31. He finished his rookie season with 14 receptions for 304 receiving yards and two receiving touchdowns in 12 games. On October 17, 2021, in Week 6, Peoples-Jones caught four passes for 101 yards and two touchdowns against the
Arizona Cardinals, including a
Hail Mary at the end of the first half. He finished the 2021 season with 34 receptions for 597 receiving yards and three receiving touchdowns in 14 games. On December 4, 2022, in Week 13, Peoples-Jones had a 76-yard punt return touchdown in a 27–14 win over the
Houston Texans, earning AFC Special Teams Player of the Week. In the following game, against the Bengals, he had eight receptions for 114 receiving yards. In the 2022 season, he finished with 61 receptions for 839 receiving yards and three receiving touchdowns.
Detroit Lions On October 31, 2023, Peoples-Jones, a Detroit native, was traded to the
Detroit Lions in exchange for a sixth-round pick in the
2025 NFL draft. On March 18, 2024, Peoples-Jones re-signed with the Lions. On August 26, 2024, Peoples-Jones was released by the Lions. He re-signed with the team's practice squad two days later on August 28.
New Orleans Saints On May 12, 2025, Jones signed with the
New Orleans Saints. He was released by New Orleans on August 21. ==Career statistics==