Early work and breakthrough (2020–present) Saleem made her acting debut with a supporting role of Erum Jameel in
Dil Ruba starring
Hania Amir and
Mohib Mirza. She received a nomination for a
Lux Style Awards for Best Emerging Talent in Television. The same year, she starred in a leading role Zoya in family romantic series
Bhaaras opposite
Zubab Rana and
Omer Shahzad. After that, she acted in
Pardes with
Affan Waheed and
Juda Huay Kuch Is Tarha. In 2022, she portrayed an innocent Mehak in love-dramatic series
Kaisi Teri Khudgarzi opposite
Danish Taimoor in their first on-screen appearance which gained her wider popularity and recognition and the series crossed more than 1 Billion Views. In 2023, she briefly appeared in the thriller series
Jurm alongside
Wahaj Ali then in an antholology-series
Siyaah, and she portrayed as a motivational speaker in family classic series
Jaisay Aapki Marzi opposite
Mikaal Zulfiqar. She was also offered to act in
Jhok Sarkar along with
Farhan Saeed. She ended the year with her portrayal of a head-strong woman Shibra Shahmeer in the romantic series
Ishq Murshid opposite
Bilal Abbas Khan. The series emerged as the major success crossed more than 1 billion views. Writing for
Redbrick opined, "Khan's transition between two personality is "effortless". In 2024, she starred as a Pashtun woman Zamda in revenge-thriller series
Khaie In 2025, Saleem appeared as a college student in
Sanwal Yaar Piya along with
Feroze Khan and
Ahmed Ali Akbar which also marks their first project together. And it became the first Pakistani drama of 2026 to enter the 1 Billion Views Club, achieving the massive milestone also, the series was well received by audiences. In 2026, saleem going to appear in
Dar-e-Nijaat opposite
Sheheryar Munawar Siddiqui,
Nameer Khan and
Sahar Hashmi in their first on-screen appearance. == Other work and media image ==