In Ulofoshio's first career play against the
Oregon State Beavers, Ulofoshio forced a fumble on the opening kickoff. Ulofoshio finished his first career season in 2018 with two tackles and two forced fumbles. In week eleven of the 2019 season, Ulofoshio had a breakout game notching a team-leading nine tackles and a sack and a half in a 19–7 win over
Oregon State and being named the Pac-12 defensive player of the week. Ulofoshio finished the 2019 season with 47 tackles with three and a half being for a loss, three sacks, and a forced fumble. In week one of the 2020 season, he recorded ten tackles, four pass deflections, and a fumble recovery, in a win over
Oregon State. He finished the 2020 season with 47 tackles with one being for a loss, a sack, four pass deflections, two fumble recoveries, and a forced fumble. For his performance on the 2020 season he was named an honorable mention All American. He finished the 2021 season with 51 tackles with two and a half being for a loss, and a forced fumble. However, Ulofoshio missed 14 consecutive games spanning from the last six of 2021 and the first eight of 2022 with a season ending arm injury in 2021 and a torn ACL in 2022. In 2022 Ulofoshio only played in five games making just ten tackles. Ulofoshio opened the 2023 season by being named a team captain for the Huskies. In week four of the 2023 season, Ulofoshio recorded his first career interception and returned it for a touchdown, in a win over
California. In the
2023 Pac-12 Football Championship Game, Ulofoshio recorded six tackles, as he helped the Huskies beat
Oregon and win the Pac-12. For Ulofoshio's performance on the 2023 season he was named first-team all Pac-12, and second team All American. Ulofoshio was also named a semi-finalist of the
Butkus Award. ==Professional career==