Early career Cambiasso began his professional career with
Argentinos Juniors in 1995, moving to
Real Madrid in 1996 along with his brother
Nicolás Cambiasso. In 1998, he moved back to Argentina, where he played for three years with
Independiente and one with
River Plate. With some good experience under his belt, he returned to Real Madrid in 2002. He helped
Los Blancos win the
UEFA Super Cup and the
Intercontinental Cup in 2002, and the
Liga and the
Supercopa de España in 2003, also reaching the semi-finals of the
UEFA Champions League that season. Cambiasso also reached the
Copa del Rey final the following season.
Inter Milan In July 2004, Cambiasso signed with
Serie A club
Inter Milan after his contract with Real Madrid expired in June. He helped Inter win the
Coppa Italia during his first season with the club, playing regularly as a defensive midfielder, partnered in the middle of Inter's midfield with fellow Argentine
Juan Sebastián Verón. In Italy, he became known as one of the outstanding players of the 2004–05 season, along with
Milan's
Kaká. During the return match of the
2006 Coppa Italia Final, Cambiasso scored an impressive goal, the first of the match, for the 3–1 victory over
Roma. On 9 September 2006, he scored twice in the opening game of the season, with Inter defeating
Fiorentina 3–2. On 7 November 2007, he along with
Zlatan Ibrahimović scored a brace apiece to defeat
CSKA Moscow 4–2 in the
Champions League. On 23 December, Cambiasso scored the winning goal for Inter as they came from behind to defeat city rivals Milan 2–1 in the
Derby della Madonnina. On 23 March 2009, it was announced that Inter and Cambiasso had come to terms about a contract renewal, extending his contract at the club until 2014. He was very important in the
2009–10 UEFA Champions League win as well, scoring the second goal of a 2–1 victory over
Chelsea at the
San Siro, a result which ultimately helped Inter go on to win the final, 2–0, against
Bayern Munich on 22 May 2010. In a
Champions League match against
Twente on 24 November, Cambiasso scored the game's only goal, securing a place in the knockout round for the holders. On 9 January 2011, Cambiasso scored twice as Inter came from a goal down to defeat
Catania 2–1. Cambiasso received the first red card of his Inter career on 30 March 2013 for a reckless tackle on
Sebastian Giovinco; he was suspended for one match. On 22 September 2013, Cambiasso scored Inter's sixth goal in their 7–0 hammering of newly promoted club
Sassuolo. Four days later, Cambiasso helped Inter come from a goal down at home to Fiorentina, scoring Inter's first goal in their 2–1 victory. At the end of the
2013–14 season, Cambiasso left Inter as his contract expired and he was not offered an extension. Technical director
Piero Ausilio said, "He waited for our decision until now, and for that he must be thanked, but I'm convinced that in his future he'll have a role at Inter."
Leicester City On 28 August 2014, Cambiasso signed a one-year deal with newly promoted
Premier League club
Leicester City, joining on a free transfer, having been released by Inter at the end of their
2013–14 season. In his first interview since joining the club, Cambiasso cited the club's desperate pursuit of him and the lure of Premier League football as the reasons he signed. He was called up for his first game three days after signing, a 1–1 draw at the
King Power Stadium against
Arsenal, as an unused substitute. Cambiasso made his debut for Leicester on 13 September against
Stoke City, coming on as a half-time substitute and impressing in the club's 1–0 win, their first of the league season. His first goal was an equaliser as Leicester beat
Manchester United 5–3 at home after trailing 1–3 with 30 minutes to play. Cambiasso scored his second goal of the season, an opener in the fourth minute following an assist from
Leonardo Ulloa, in a 3–2 loss against
Queens Park Rangers at
Loftus Road. That was Leicester's first goal in 504 minutes without scoring, or 56 days. On 4 April 2015, Cambiasso gave Leicester a 12th-minute lead against
West Ham United in a game that
the Foxes would go on to win 2–1, their first league victory in eight matches, stretching back to 10 January 2015. This started a run of seven wins and one draw from Leicester's final nine Premier League fixtures, with the team finishing 14th in the table. On 18 May 2015, at Leicester City's annual awards, Cambiasso's impressive performances over the course of the season saw him pick up the Player of the Year award, as voted by the club's supporters. On 24 May, Cambiasso scored in a 5–1 defeat of QPR in Leicester's final match of the Premier League season.
Olympiacos On 7 August 2015, Cambiasso signed a two-year deal with Greek giants
Olympiacos. He scored his first goal for them on 2 December in a 4–0 away win against
Panegialios in the group stage of the
Greek Cup. He scored twice in 14
Super League Greece games as the
Piraeus-based side retained their title, including the equaliser in a 3–1 home win over
Panathinaikos in the
Derby of the eternal enemies on 13 March 2016. Eleven days earlier, the first leg of the cup semi-final against
PAOK, he scored in a 2–1 away win which was abandoned due to violence by the local fans. Cambiassio renewed his contract on 11 July 2016. On 9 March 2017, he returned to the starting lineup as a result of the dismissal of Olympiacos manager
Paulo Bento against
Beşiktaş for the first leg of the
UEFA Europa League round of 16 stage, and headed the opening goal of a 1–1 draw, subsequently being named
man of the match.
Retirement On 8 September 2017, Cambiasso announced his retirement from professional football, two months after his contract with Olympiacos expired. Cambiasso's success in the official
UEFA A Licence examinations in
Coverciano, subsequently allowing him to take up an assistant role in
Serie A or
B or head coach role
Serie C in the future, influenced his decision to retire from the game. ==International career==