Borage seed oil

Effects GLA is converted to dihomo-γ-linolenic acid (DGLA), a precursor to a variety of the 1-series prostaglandins and the 3-series leukotrienes. It inhibits leukotriene synthesis to provide therapy in rheumatologic illness. There is insufficient scientific evidence to determine the effectiveness of borage for a majority of these uses. Its efficacy to treat eczema was not better than placebo when taken orally. ==Safety==

Adverse effects Borage oil may contain the pyrrolizidine alkaloid amabiline, which is hepatotoxic leading to a risk of liver damage. Seizures have been reported as a complication of ingestion of borage oil in doses of 1,500 to 3,000 mg daily, although a mixed review of borage oil's effect on seizure thresholds indicates that borage oil quality varies. A specific extraction process may offer purified products with 50%+ GLA content. Borage seed oil might prolong bleeding time, increase the risk of bruising and bleeding, and increase the risk of bleeding during and after surgery. Interactions Because borage oil can theoretically lower the seizure threshold due to its GLA content, it could therefore trigger a seizure in users of phenothiazines or tricyclic antidepressants. Use of NSAIDs with borage oil may theoretically decrease the effects of borage oil, as NSAIDs interfere with the synthesis of prostaglandin E. == References ==