Main •
Ella Purnell as Lucy MacLean, a
Vault 33 Dweller • Luciana VanDette (guest season 1) and Grace Kelly Quigley (guest season 2) portray young Lucy MacLean •
Aaron Moten as Maximus, a squire of the
Brotherhood of Steel and later ally of Lucy • Amir Carr portrays young Maximus (guest seasons 1–2) •
Kyle MacLachlan as Hank MacLean, Lucy and Norm's father and Overseer of Vault 33 •
Moisés Arias as Norm MacLean, Vault 33 resident and Lucy's younger brother • Cody Alexander Guevara portrays young Norm MacLean (guest season 2) •
Xelia Mendes-Jones as Dane (season 1; recurring season 2), a scribe of the Brotherhood of Steel •
Walton Goggins as
Cooper Howard / The Ghoul, a Hollywood actor and
Vault-Tec ambassador before the Great War, who mutated into a
ghoul and is now a
gunslinger and
bounty hunter •
Frances Turner as Barb Howard (season 2; recurring season 1), Cooper's wife and high-ranking Vault-Tec executive
Recurring •
Sarita Choudhury as Kate Williams / Lee Moldaver (season 1; guest season 2), a nuclear scientist who survived the Great War and later became a
New California Republic (NCR) commander •
Leslie Uggams as Betty Pearson, Vault 33 councillor and later Overseer • Princess Bey portrays young Betty Pearson (guest seasons 1–2) •
Johnny Pemberton as Thaddeus, a squire of the Brotherhood of Steel •
Zach Cherry as Woody Thomas (season 1; guest season 2), Vault 33 councillor • Annabel O'Hagan as Stephanie Harper, pregnant Vault 33 resident. In the second season, she becomes the overseer of Vault 32. • Dave Register as Chet, Lucy and Norm's cousin and Vault 33 gatekeeper • Rodrigo Luzzi as Reg McPhee, Vault 33 councillor • Leer Leary as Davey, Vault 33 resident • Elle Vertes as Rose MacLean (season 1), Lucy and Norm's mother • Teagan Meredith as Janey Howard (season 1; guest season 2), Cooper's daughter •
Michael Cristofer as Elder Cleric Quintus (season 2; guest season 1), Maximus' superior and leader of the Brotherhood of Steel's San Fernando chapter •
Jon Daly as the Snake Oil Salesman (season 2; guest season 1), who is a mercantile denizen of the wasteland •
Justin Theroux as Robert Edwin House (season 2), the CEO of RobCo Industries and ruler of the New Vegas Strip in 2281. He previously appeared in the video game
Fallout: New Vegas. • Rafi Silver portrays a body-double version of the character (season 2; guest season 1) •
Rachel Marsh as Claudia (season 2), a novice Vault-Tec employee who was cryogenically frozen in Vault 31 • Adam Faison as Ronnie McCurtry (season 2), Bud Askin's former assistant and one of the Vault-Tec employees who were cryogenically frozen in Vault 31 • Rajat Suresh and Jeremy Levick as Clark and Pete (season 2), part of the group of Vault-Tec employees who were cryogenically frozen in Vault 31 •
Martha Kelly as Representative Diane Welch (season 2), a pre-apocalypse congresswoman for the district of Glendale •
Jon Gries as Biff (season 2), a ranger for the New California Republic
Guest ;Introduced in season 1 •
Mykelti Williamson as Honcho, a bounty hunter who revives Cooper from imprisonment •
Matt Berry as: • "Mr. Handy", a General Atomics helper bot in 2077 • "Snip Snip", a Mr. Handy turned organ harvester • Sebastian Leslie, an English actor who provided the voice of the Handys, and Cooper's pre-apocalypse friend • Cameron Cowperthwaite as Monty, a raider who "married" Lucy as part of a ruse to kidnap Hank • Jacinto Taras Riddick as Cleric Felix, high-ranking member of the Brotherhood of Steel • Joel Marsh Garland and Jacob A. Ware as Biggie and Slim, Honcho's minions •
Mike Doyle and Janie Brookshire as Bob Spencer and Rhonda Spencer, Cooper's pre-apocalypse employers for their child's birthday party •
Michael Emerson as Dr. Siggi Wilzig (seasons 1–2), an enigmatic defector from the
Enclave whose head carries the solution to Cold Fusion •
Michael Rapaport as Knight Titus, whom Maximus initially serves and later impersonates •
Dale Dickey as Ma June (seasons 1–2), a cantankerous shopkeeper in the settlement of Filly • Edythe Jason as Barv (seasons 1–2), June's partner and a resident of Filly • Michael Abbott Jr. as a lonesome farmer living just outside Filly •
Neal Huff as Roger, a ghoul and friend of Cooper's, slowly succumbing to ferality •
Michael Esper as Bud Askins / Brain-on-a-Roomba (seasons 1–2), a senior junior vice president at Vault-Tec in 2077 and the Overseer of Vault 31 post-war •
Matty Cardarople and Elvis Valentino Lopez as Huey and Squirrel, a pair of bumbling organ harvesters •
Chris Parnell as Benjamin, the
Cyclops Overseer of Vault 4 •
Cherien Dabis as Birdie, a surface-born resident of Vault 4 and former resident of Shady Sands •
Glenn Fleshler as Sorrel Booker, the self-titled "President" of The Govermint (
sic) who seeks to maintain order in the Wasteland •
Dallas Goldtooth as Charles Whiteknife (seasons 1–2), a pre-apocalypse actor friend of Cooper's • Eric Berryman as Lloyd Hawthorne, the first overseer of Vault 4 •
Angel Desai as Cassandra Hawthorne, Lloyd's wife •
Fred Armisen as DJ Carl, the host of an old-timey radio station •
Erik Estrada as Adam, a former ranger for the New California Republic turned farmer whose son is affiliated with Moldaver •
Michael Mulheren as Frederick Sinclair, a representative of Big MT and the founder of the Sierra Madre Casino •
James Yaegashi as Leon Von Felden, a top West-Tek executive • Rebecca Watson as Julia Masters, a top REPCONN executive ;Introduced in season 2 • Susan Berger as Old Woman Gretch, an elderly soup seller • Jared Bankens as Nick the Prick, the leader of the Great Khans raiders •
Christopher Matthew Cook as Bill, a pre-apocalypse bar patron •
Kumail Nanjiani as Paladin Xander Harkness, a liaison to the Commonwealth Brotherhood of Steel •
Bashir Salahuddin and Shinelle Azoroh as Joseph and Julia, Maximus's father and mother •
Brian Thompson, Sisa Grey, and
Chris Browning as the Coronado Elder, Yosemite Elder, and Grand Canyon Elder, the cleric leaders of separate Brotherhood of Steel chapters •
Judson Mills as Stephen Winthrop, a rich businessman cryogenically frozen by Vault-Tec • Tim Soergel as Gnatius, a knight of the Brotherhood •
Macaulay Culkin as Lacerta Legate, a high-ranking member of Caesar's Legion, a society inspired by Ancient Roman traditions •
Barbara Eve Harris as Rodriguez, a captain of the New California Republic • Guy Heilweil, Ava Scarola, and Alyssa Riley Ndati as Perry, Lois, and Trudy, children who work in Thaddeus' factory • Ciel Shi as Wenjie, a pre-apocalypse Chinese soldier •
Edwin Lee Gibson as Shotgun Jeff, a bartender in New Vegas • Tony Robinette as Simon, the shopkeeper for the Sunny's Sundries general store in New Vegas •
Ron Perlman as a super mutant who encounters Cooper •
Clancy Brown as the last pre-apocalypse President of the United States •
Natasha Henstridge as Joan, Stephanie's pre-apocalypse mother who attempts to escape with her from Canada == Episodes ==