His father
Francesco Maria II della Rovere was popularly urged to remarry after the death of his first wife in 1598, with the marriage producing no heirs. In 1599, he married his cousin
Livia della Rovere, granddaughter of
Giulio della Rovere, with Federico Ubaldo being the product of said marriage. At the age of 16 he succeeded to the Duchy of Urbino on 3 November 1621. This same year, in order to produce an heir himself, he married
Claudia de' Medici, daughter of
Ferdinando I de' Medici, Grand Duke of Tuscany and
Christina of Lorraine. The following year, Claudia gave birth to a daughter
Vittoria della Rovere. He was to be in the fold of
enlightened absolutism upheld since
Francesco Maria I della Rovere. In 1623, Federico died in Urbino. He was likely poisoned, but autopsy results claim that he died with an
epileptic seizure. The funeral took place on the following Sunday, 2 July, and was accompanied by the whole clergy. The confraternity and 125 high noblemen, all dressed in mourning, with a torch in their hands, the funeral procession went through the city, in front of the whole population of the city of Urbino. His father decided to allow his state to be subsumed into the
Papal States. Their daughter married the
Grand Duke of Tuscany in 1633 but her bloodline died out in 1743. ==Issue==