Roma Youth squad Born in
Sunyani, Ghana, Afena-Gyan moved to
Serie A side
Roma's
youth team on 13 March 2021, from EurAfrica FC. Just a day after being unveiled on 13 March, he made his debut for AS Roma's under-18 team, scoring and assisting in a 5–0 win over
Genoa. He then scored in his next two games for the under-18
and due to his immediate impact he was quickly promoted to Roma's Primavera under-19 squad managed by
Alberto De Rossi, where he scored four and assisted two in 15 appearances to finish the season. He made his professional debut on 27 October, against
Cagliari. On 21 November, he came off the bench to score two late goals against
Genoa, to give Roma a 2–0 win. The brace made him the first player born in 2003 to score in the Serie A.
José Mourinho, AS Roma's manager promised to buy Afena-Gyan a pair of shoes that cost €800 if he scored a goal. After scoring, he ran to Mourinho's bench to remind him of his promise. On 6 July 2022, he officially renewed his contract with Roma until 2026.
Cremonese On 29 August 2022, Afena-Gyan was signed by newly promoted Serie A club
Cremonese on a permanent deal. On 20 October, he scored his first goal for the club in a 4–2
Coppa Italia win over
Modena after the
extra time. On 17 January 2023, during the match of the cup's round of 16 against
Napoli, the forward scored the equalizer (2–2) for Cremonese at the 87th minute, taking the game to the extra time. The match ended up in a
penalty shoot-out, with Afena-Gyan himself scoring the last attempt of his side and allowing Cremonese to qualify for the quarter-finals of the tournament.
Loan to Amedspor On 20 August 2025, Afena-Gyan was loaned to
Amedspor in Turkish second tier
TFF 1. Lig, with an option to buy. He made his debut for the Turkish side on August 24, 2025, in their 4-2 win against Sivasspor. He came in on the 81st minute and played 9 minutes in that match. == International career ==