2019–2020: ATP debut Cerúndolo made his ATP main draw debut on home soil at the
2019 Argentina Open in
Buenos Aires after receiving a wildcard for the singles main draw, losing to
Guido Pella in three sets. Cerúndolo played another ATP main draw a year later at the
2020 Argentina Open in Buenos Aires after receiving a wildcard for the singles main draw again, losing to
Laslo Djere in the first round.
2021: First ATP final at home, Major and Olympics debuts In January 2021, he was one of two players to test positive for
COVID-19 during the
Australian Open qualifying event in
Doha. Cerúndolo reached his first ATP tour final at the
2021 Argentina Open as a qualifier but was defeated by world No. 9
Diego Schwartzman. He was the first qualifier to reach the final in Buenos Aires since
José Acasuso in 2001. At the time, Acasuso was coached by Cerúndolo's father, Alejandro Cerúndolo. Cerúndolo made his main draw debut in a Grand Slam at the
2021 French Open as a
lucky loser, where he lost to
Thiago Monteiro. Cerúndolo qualified to represent Argentina at the
2020 Summer Olympics.
2022: ATP 1000 semifinal, maiden title, top 30 At the
2022 Argentina Open, he reached the quarterfinals of his home tournament as a qualifier defeating
Miomir Kecmanović. As a result, he reached the top 100 in the singles rankings, joining
Juan Manuel Cerúndolo as the first brothers in the Top 100 at the same time since
Alexander Zverev and
Mischa Zverev in May 2019. Cerúndolo received a
special exempt into the tournament in
Rio de Janeiro the following week. There, he beat
Benoît Paire,
Roberto Carballés Baena and again Kecmanović to reach his first ATP 500 semifinal, where he lost in straight sets to
Diego Schwartzman. Cerúndolo recorded his first ATP Tour victories on a hard court at the
Masters 1000 event in
Miami, defeating
Tallon Griekspoor and seeded players
Reilly Opelka and
Gaël Monfils en route to the fourth round. He beat
Frances Tiafoe (who defeated his brother
Juan Manuel in the third round) in the fourth round to advance to the quarterfinals. He advanced to the semifinals after
Jannik Sinner retired during their match due to foot blisters. Ranked World No. 103 at the time, he became the lowest-ranked semifinalist in the history of the Miami Open, and also became the first male player since
Jerzy Janowicz in 2012 to reach the semifinals on their Masters 1000 level debut. He lost to 6th seed
Casper Ruud in the semifinals in straight sets. Following this result, his ranking rose 52 places to a career-high of World No. 51. In
Båstad, Cerúndolo recorded his first win against a player inside the Top-10 after beating top seed and defending champion
Casper Ruud in 3 sets. He proceeded to reach the final after beating
Aslan Karatsev and
Pablo Carreño Busta. He defeated
Sebastián Báez in the final to win his first ATP title. As a result, he reached the top 30 on 18 July 2022 and the top 25 a week later. At the
2022 Hamburg European Open, he reached the quarterfinals defeating World No. 8 and second seed
Andrey Rublev, his second Top-10 win. He reached his second ATP 500 semifinal by beating
Aslan Karatsev in three sets. He represented
Argentina for the first time in the
Davis Cup finals, where he lost both matches to
Jannik Sinner and
Borna Ćorić respectively.
2023: First Major win, Latin American No. 1, top 20 Cerúndolo won his two first matches at a Grand Slam at the
Australian Open after beating
Guido Pella and
Corentin Moutet to reach the third round on his debut at this Major. He played again in the Davis Cup, this time recording his first win in the tournament against
Otto Virtanen. In
Córdoba, Argentina he defeated fellow Argentine
Federico Delbonis to reach the quarterfinals but lost to eventual runner-up compatriot
Federico Coria, however, his brother
Juanma defeated
Diego Schwartzman in the same tournament, as a result, Francisco he became Argentine No. 1 and Latin American No. 1 player on 13 February 2023. In
Buenos Aires, Argentina he defeated
Yannick Hanfmann and
Jaume Munar to reach back to back quarterfinals but lost to
Bernabé Zapata Miralles. He reached back-to-back quarterfinals at this tournament defeating
Lorenzo Sonego. In
Barcelona he defeated world No. 3
Casper Ruud in the third round, his second top-10 win to reach the quarterfinals. In
Madrid he lost in the second round to compatriot
Pedro Cachin having a bye in the first round. In
Rome he reached his second Masters quarterfinal of the season defeating
Wu Yibing,
Grégoire Barrère and world No. 8
Jannik Sinner, for his third top-10 win. In
Lyon he reached a new ATP Tour final, beating
Juan Pablo Varillas,
Jack Draper, and
Cameron Norrie, in the title match he lost against
Arthur Fils in straight sets. He picked up the third Major win of his career at the
French Open, where he defeated
Jaume Munar in four sets. Next he defeated lucky loser
Yannick Hanfmann. He reached the round of 16 for the first time at a Major defeating ninth seed
Taylor Fritz, his fourth top-10 win of the season. He lost to sixth seed
Holger Rune in five sets with a fifth set tiebreaker. As a result, he reached the top 20 in the rankings on 12 June 2023. In
Eastbourne he became the third Argentinian champion on grass after
Guillermo Vilas and
Javier Frana, and the first since 1995, defeating
Marc-Andrea Hüsler,
Zhang Zhizhen,
Mackenzie McDonald and second seed
Tommy Paul, beating both Americans in the same day. He recorded his first win at the
2023 Wimbledon Championships defeating
Nuno Borges. On his return to clay at
Båstad, he started his title defense beating
Luca Van Assche in the second round,
Federico Coria in the quarterfinals, but lost in the semifinals to eventual champion
Andrey Rublev. At the
US Open he beat
Zachary Svajda in the first round, his first win at this Major. On his debut at the
Laver Cup he recorded the first ever win for South America at the event against
Alejandro Davidovich Fokina. In
Paris he reached the third round defeating
Gaël Monfils and world No. 8
Casper Ruud, for his fifth top-10 win of the season.
2024: Third ATP 500 semifinal, Olympics debut, 100th win The start of the season in the
Australian Open Series began with three defeats in second rounds, first at
Hong Kong Open, then at the
ASB Classic, and the last at the
Australian Open, where he lost against
Fábián Marozsán in straight sets. He was called up again for
Argentina to play at the
Davis Cup qualifying round, this time against
Kazakhstan, he won the first match of the series against
Dimitry Popko, giving his country the first point, after the defeat over
Tomás Martín Etcheverry and the victory over
González/
Molteni, Francisco lost against
Timofey Skatov leaving the series 2-2, however,
Sebastián Báez won against Popko and Argentina won the series 3–2, qualifying for the David Cup Finals. Seeded fourth, he reached the semifinals at the ATP 500
2024 Rio Open for the second time at this tournament, but lost to fifth seed and eventual champion
Sebastian Baez. He reached his fifth ATP final at the
2024 Croatia Open Umag defeating
Lorenzo Sonego and upsetting top seed
Andrey Rublev. He won his third title defeating 2nd seed
Lorenzo Musetti in three sets. In less than 24 hours, he recorded his first win at the
Paris Olympics over Chilean
Tomás Barrios Vera. He then defeated 10th seed
Ugo Humbert but lost to
Casper Ruud in straight sets. Seeded fourth, he reached the semifinals at the
2024 Almaty Open, but lost to
Gabriel Diallo. At the
2024 Rolex Paris Masters Cerundolo again upset sixth seed Andrey Rublev in straight sets with two tiebreaks recording his 100th tour-level win. It was his fourth Top 10 win of the season and second over Rublev (after Umag).
2025: Back-to-back Masters quarterfinals & first clay semifinal, back to top 20 He reached the final at his home tournament, the
2025 Argentina Open, defeating top seed
Alexander Zverev en route, but lost in straight sets to
João Fonseca, who became the youngest Brazilian to win an ATP title in the
Open Era. At the
2025 Chile Open as the top seed, he reached his second semifinal at the Golden swing with a win over compatriot
Tomás Martín Etcheverry. At the
2025 BNP Paribas Open in Indian Wells he reached the quarterfinals of a Masters for the fifth time in his career and first at the tournament, defeating ninth seed
Alex de Minaur, his 13th top 10 win, before losing to
Carlos Alcaraz. In
Miami he defeated
Alexandre Müller, 12th seed
Tommy Paul and fifth seed
Casper Ruud, his 14th top 10 win, to reach back to back quarterfinals. It was his third quarterfinal in four appearances at the hardcourt Masters in Miami. Cerundolo reached also the quarterfinals at the clay Masters 1000, the
2025 Mutua Madrid Open, with another win over top seed Alexander Zverev, his second clay win over the German player in the season (after Buenos Aires), bringing their head-to-head to 3–0. He reached only his second Masters semifinal and first on clay with a win over 22nd seed
Jakub Menšík. He lost to 14th seed Casper Ruud in straight sets.
2026: Fourth career title At the
Australian Open third round, he defeated 13th seed
Andrey Rublev in straight sets, reached fourth round for the first time. At the
Argentina Open, he reached back-to-back final defeating
Hugo Dellien,
Vít Kopřiva, and 7th seed
Tomás Martín Etcheverry. He won his fourth title defeating 2nd seed
Luciano Darderi in straight sets. ==Personal life==