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George Clarke (British politician) (1661–1736), Secretary at War •
George Clarke (governor) (1676–1760), colonial New York, 1736–1743 •
George Clarke (New Zealand pioneer) (1823–1913), pioneer and educationist •
George Clarke, 1st Baron Sydenham of Combe (1848–1933), British colonial administrator •
George W. Clarke (Iowa politician) (1852–1936), governor of Iowa •
George W. Clarke (Newfoundland politician) (1910–2000), Newfoundland lawyer and politician •
George W. Clarke (Washington politician) (1906–2006), American politician in the state of Washington •
George Johnson Clarke (1857–1917), premier of New Brunswick •
George Clarke (Canadian politician) (1827–?), politician in Nova Scotia •
George Clarke (judge) (1798–1875), New Zealand missionary, teacher, public servant, politician and judge •
George J. F. Clarke (1774–1836), active in East Florida in the Second Spanish Period •
George L. Clarke (1813–1890), mayor of Providence, Rhode Island •
George Thomas Clarke (1853–1925), Australian local government politician ==Sport==