At Oxford he met
John Nelson Darby and
Benjamin Wills Newton. Dissatisfied with the established church, Wigram and his friends left the Anglican church and helped establish non-denominational assemblies which became known as the
Plymouth Brethren. He had considered joining
Anthony Norris Groves and his mission to
Baghdad in June 1829, but changed his mind just prior to the faith mission set off. After leaving Oxford University, Wigram, using his family wealth, in 1831 bought church premises in Plymouth and there established a Brethren assembly. During the 1830s Wigram also financed the establishment of assemblies in London. Wigram had a keen interest in the original Hebrew and Greek texts of the Bible, which was of great interest to the emerging Brethren assemblies. In 1839, after years of work and financial investment, he published ''The Englishman's Greek and English Concordance to the New Testament
, followed in 1843 by The Englishman's Hebrew and Chaldee Concordance to the Old Testament
. He also edited the influential Brethren periodical Present Testimony and Original Christian Witness'' for many years (from 1849 to his death with posthumous issues running to 1881). This periodical superseded the Brethren's first magazine,
The Christian Witness. Besides his literary work his oral ministry was considered to be marked by an attractive freshness: a contemporary remarked that his "very face became radiant as he spoke". Many of his addresses have been preserved and published in the two volumes
Memorials of the Ministry of G.V. Wigram and
Gleanings from the Teaching of G.V. Wigram. These were collected by the erstwhile Lewisham Road
Baptist Church Minister,
Edward Dennett. With Wigram's help, Darby became the most influential personality within the Brethren movement. Wigram is often referred to as being Darby's lieutenant as he firmly supported Darby during moments of crisis. In 1845 he supported Darby in his doctrinal differences with Benjamin Wills Newton in the Brethren assembly at Plymouth. In Darby's 1848 dispute with
George Müller, Wigram again sided with Darby in relation to the reception of believers who had previously been in fellowship with Newton, and on Müller's reluctance to publicly denounce errors by Newton in regards to the sufferings of Christ (errors which Newton had already retracted). He also helped Darby fend off accusations of heresy, also in regards to the sufferings of Christ, in articles written in 1858 and 1866, which some considered were very similar to Newton's errors two decades earlier. ==Married life==