In 1579, Gevherhan Sultan married
Cerrah Mehmed Pasha, and they had a son, Sultanzade Salih Bey. When he was promoted from the generalship of the janissaries to the governorship of Rumelia in March 1580, people opined that it was due to the political power of Gevherhan Sultan. In 1583, he presented
Handan Hatun to then Prince Mehmed (later
Mehmed III) on his departure for Manisa. In 1598, when her husband was appointed the grand vizier during Mehmed III's reign, Gevherhan became an influential political figure in court circles. This position seems to have enabled her to keep in touch with Mehmed III's sons and their mothers as well. Gevherhan was known to be extremely jealous of this husband. On one occasion, she was reported to have stabbed one of her
Kalfa because she believed she was provoking her husband. Gevherhan wrote many letters to her youngest son, Sultanzade Salih Bey, who was the governor of Klis. These letters were considered so important from a political point of view that their translations were sent in Venice by the baylo. She also protected her daughter's husband Sinanpaşaoğlu Mehmed Pasha. She was on friendly terms with Süleyman Agha, the mute of
Safiye Sultan. Soon after his succession,
Ahmed I, Mehmed's son by Handan, wanted to express his gratitude to Mehmed Pasha and Gevherhan Sultan for the role they had played in bringing his parents together. By then, however, Cerrah Mehmed Pasha was old and ailing, and died on 9 January 1604. Ahmed, therefore, honored the late pasha's wife. Venetian bailo Contarini records that "having remembered this [i.e., his mother’s background], he sent the sultana [Gevherhan] a thousand gold coins and a sable robe with many other gifts as a sign of welcome, since she had been the origin of his good fortune and of the greatness in which at present he found himself." Ahmed also named one of his
daughters after Gevherhan to further mark his great-aunt's role in his life. Her daily stipend consisted of 350 aspers. ==Charities==