Only two of Ismihan's five children survived after infancy. From her first marriage, Ismihan had a daughter and three sons: • Safiye Hanımsultan (1563 – 24 January 1593). Ismihan Sultan's eldest child. She was firstly married to her father's cousin Sokollu Mustafa Pasha, governor of Buda. After his execution in 1578, she married the new governor of Buda, Silahdar Cafer Pasha. After his death in 1587, she gave birth to their twin sons, Mehmed Bey and Cafer Bey, who died as children. She married thirdly to Sultanzade Abdülbaki Bey, son of her mother's cousin
Hümaşah Sultan. • Sultanzade Ahmed Bey (1564 – 1567). Died in infancy, probably of smallpox. • Sultanzade Sokolluzâde Ibrahim Han Pasha (1565 – 1621). In 1924, one of his descendants, Sokolluzade Abdülbâki Ihsân Bey, married another Ottoman princess,
Rukiye Sultan, granddaughter of Sultan
Mehmed V. • Sultanzade Piri Mehmed Bey (1566 – 1567). Died in early infancy, probably of smallpox. From her second marriage, Ismihan had a son: • Sultanzade Mahmud Bey (5 August 1585 – 24 September 1585). Ismihan died giving birth to him. He died 50 days after his mother. ==Charities==