Kaifee started her acting career in 1976 with the title role in
PTV's
Shama which was written by
Fatima Surayya Bajia. She was encouraged by Qasim Jalil to pursue a career in television when Bajia decided to cast her in her
Shama. In 1977 she was offered the lead role of Rita opposite
Nadeem in film
Aina by director
Nazar-ul-Islam and written by
Bashir Niaz but she refused it because her husband didn't wanted her to act in the film then the role was offered to
Shabnam which she accepted the film was a Diamond Jubilee at the box office later Ghazala admitted that she regretted for refusing it when she saw the movie in cinema. She was noted for her roles in dramas
Shama,
Tipu Sultan: The Tiger Lord,
Ana,
Hawain,
Aroosa and
Brahim Ki Talaash. She also appeared in dramas
Yeh Bhi Kisi Ki Bayti Hai,
Janay Kyun,
Chain Aye Na,
Rasam,
Rishtay Mohabbaton Kay and
Laikin. Ghazala also appeared in the movie
Article 370 as Mir's mother. Since then she appeared in dramas
Ishq E Laa,
Qissa Meherbano Ka and
Sinf-e-Aahan. ==Personal life==