By 1316 Orsini was at the
papal palace in
Avignon serving his cousin
Cardinal Napoleone Orsini, through whose offices in September 1316 he was appointed
archdeacon of
Bibiesca,
Burgos, and a
protonotary apostolic. In the
consistory of 17 December 1316 he was created
cardinal deacon of
San Teodoro and in 1317 received the title of
San Marco in commendam. The interests of the Pope were more scholarly than political, and he entrusted many practical decisions to Orsini. At the end of 1327, an embassy from Rome to Avignon offered the Pope a stark
ultimatum: if he did not immediately return to the city, Rome would submit to his opponent
Ludwig of Bavaria. The Pope declined to be commanded, and Orsini attempted to enter Rome but was turned away, retaliating by placing an
interdict on the city. In January 1328 Ludwig was crowned
Holy Roman Emperor in Rome and installed as
Antipope Nicholas V. However, Ludwig was almost entirely dependent in Rome on
Sciarra Colonna and lacked the support of
Stefano Colonna the Younger. In the summer of 1328, his remaining support melted away when
Robert, King of Naples, sent a fleet to
blockade the port of
Ostia, while Orsini massed forces outside the city. Ludwig and his antipope fled the city on 4 August, and Orsini entered it triumphantly on Sunday, 8 August. Ten days later an
Angevin army led by
William, Count of Eboli, marched into Rome in the name of Robert of Naples. Late in 1328, Orsini began a campaign against
Corneto and
Viterbo, which were harbouring the antipope. Both cities submitted to papal authority in 1329. The same year, the antipope also surrendered himself to the Pope, while Ludwig remained as a powerful enemy of the Pope in his
Empire to the north. In August 1334, the Pope cancelled Orsini's legation. Orsini returned to Avignon, where he remained until his death a year later. He died on 27 August 1335 at Avignon and was entombed there in the church of the
Franciscans. ==Likeness==