Ressler was awarded a football scholarship to
Penn State University in the fall of 1961, on track to soon play for the
Nittany Lions. On the offensive side of the ball, Ressler continued to fill the guard position he had occupied as a sophomore. The Penn State athletic department began touting Ressler as a potential
All-American for 1964, with publicity director Jim Tarman noting: "If we have an All-America candidate next year, he's it. He's a big farm boy from Dornsife, up the river from
Harrisburg, and right now he's our toughest lineman." Penn State line coach
Jim O'Hora noted that the now 230-pound Ressler should be one of the best defensive linemen of 1964 if he wasn't already. "He has the knack for coming up with the big play," O'Mora said. Penn State's defense was indeed special in 1963, giving up just 92 points through 9 games and finishing the season with a record of 7–3 and a No. 16 national ranking in the coaches poll. Ressler finished the 10 games of his junior 1963 season with 7 quarterback sacks, 3 fumble recoveries, an interception, 53 unassisted tackles, and 30 assists. The enthusiastic coach told another reporter of his senior two-way line star, "Ressler is big, strong, quick, a fine tackler, and what else do you need? On offense he excels at blocking the man over center and clearing the way for our inside attack. He snaps the ball well for punts and on hand-ups. Defensively he's a rugged tackler and difficult to block. Most important of all, he has the temperament to be great." Particularly notable for the Nittany Lions in 1964 would be a 27–0 upset shutout of #2 ranked
Ohio State at
Columbus before a crowd of over 84,000 people. Ressler had 15 tackles in the game. Ressler — called "Zeke" by his Penn State teammates — was chosen as winner of the
Maxwell Award as college football's best all-around player of 1964. He was a "consensus All-American," although named in a variety of positions — as an offensive center to the 22-man
two platoon team of the
Newspaper Enterprise Association, as a guard to the 11-man single platoon first team picked by the
American Football Coaches Association, and so forth. The versatile Ressler was named to various All-American teams as an offensive center and guard, and a defensive guard, tackle, and linebacker. Ressler was also named as college football Lineman of the Year for 1964 by the Philadelphia Sportswriters' Association. As a national star and a graduating senior, Ressler had multiple offers to appear in post-season college all-star games. He elected to play for the East in the
East–West Shrine Game held in
San Francisco on January 2, 1965, and in the 1965
Hula Bowl held in
Honolulu one week later. Ressler majored in Agricultural Education at Penn State, receiving his
Bachelor of Science degree in 1966. ==Professional career==