Professional baseball was first played in
Greeneville, Tennessee, by the
Greeneville Burley Cubs in the
Appalachian League in 1921. They remained in the league through 1925 and returned for a second stretch from 1938 to 1942. While the team bore the name of Greeneville, they would play their home games at
Pioneer Park located in nearby
Tusculum on the campus of
Tusculum College. the Astros played their first game on June 21, 2004, on the road against the
Elizabethton Twins at
Joe O'Brien Field, winning 3–1. They completed their inaugural season with a first place 41–26 record, the all-time franchise highest. Having won the Western Division title, Greeneville then defeated the
Danville Braves, 2–1, in a best-of-three series to win the
Appalachian League championship. Bogar was selected for the league's Manager of the Year Award, and
outfielder Mitch Einertson won Player of the Year honors. The Astros missed the playoffs for the next eight seasons, often finishing fourth or fifth out of five teams in the Western Division. The 2007 team set a franchise record low win–loss record with a 17–51 season. They won their semifinal match-up versus the
Kingsport Mets, 2–1, but lost in the finals to the
Pulaski Mariners, 2–0. They defeated Kingsport in the semifinals, 2–1, then won their second Appalachian League championship with a 2–1 series win over the
Princeton Rays. In 2017, the Astros again finished second (33–34) to earn a playoff spot under manager Danny Ortega. They were, however, eliminated by the
Elizabethton Twins, 2–1, in the semifinals with a 6–0 shutout road loss on September 6. The Houston Astros announced two days later that they were eliminating their Appalachian League team in Greeneville so as to strengthen their player development efforts by reducing their farm system from nine teams to eight. Over 14 years in Greenville, the Astros led the Appalachian League in total and average attendance at Pioneer Park from 2004 to 2014. Their all-time regular season record was 440–498 (.469). In 2018, the
Cincinnati Reds took Greeneville's place in the Appalachian League with the
Greeneville Reds. ==Season-by-season results==