HDAC1

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. == Interactions ==

HDAC1 has been shown to interact with: • Androgen receptor, • BCL6, • BTG2, • BUB1B, • CDC20, • CDH1, • CTBP1, • DDX17, • DNMT3A, • DNMT3L, • Death-associated protein 6, • EED, • EZH2, • GATA1, • HMG20B, • Homeobox protein TGIF1, • Host cell factor C1, • IFRD1, • IKZF1, • ING1, • MBD3, • MIER1, • MLL, • MTA1, • MTA2, • Methyl-CpG-binding domain protein 2, • Mothers against decapentaplegic homolog 2, • MyoD, • NFKB1, • P21, • PCNA, • PHF21A, • Prohibitin, • Promyelocytic leukemia protein, • RAD9A, • RBBP4, • RBBP7, • RCOR1, • RFC1, • Retinoblastoma protein, • Retinoblastoma-like protein 1, • Retinoblastoma-like protein 2, • SAP30, • SATB1, • SIN3B, • SUDS3, • SUV39H1, • Sp1 transcription factor, • TOP2A, and • Zinc finger and BTB domain-containing protein 16. == See also ==