depicting
Cassander, first post-
Argead leader of Hellenistic Greece and founder of
Thessaloniki The quests of
Alexander had a number of consequences for the Greek city-states. It greatly widened the horizons of the Greeks, making the endless conflicts between the cities which had marked the 5th and 4th centuries BC seem petty and unimportant. It led to a steady emigration, particularly of the young and ambitious, to the new Greek empires in the east. Many Greeks migrated to Alexandria, Antioch and the many other new Hellenistic cities founded in Alexander's wake, as far away as what are now
Afghanistan and
Pakistan, where the
Greco-Bactrian Kingdom and the
Indo-Greek Kingdom survived until the end of the 1st century BC. The defeat of the Greek city-states by
Philip and Alexander also taught them that they could never again be powers in their own right, and that the hegemony of
Macedon and its successor states could not be challenged unless the city states united, or at least federated. The Greeks valued their local independence too much to consider actual unification, but they made several attempts to form federations through which they could hope to reassert their independence. Following Alexander's death a struggle for power broke out among his generals, which resulted in the break-up of his empire and the establishment of a number of new kingdoms. Macedon fell to
Cassander, son of Alexander's leading general
Antipater, who after several years of warfare made himself master of most of the rest of Greece. He founded a new Macedonian capital at
Thessaloniki and was generally a constructive ruler. Cassander's power was challenged by
Antigonus, ruler of Anatolia, who promised the Greek cities that he would restore their freedom if they supported him. This led to successful revolts against Cassander's local rulers. In 307 BC, Antigonus's son
Demetrius captured
Athens and restored its democratic system, which had been suppressed by Alexander. But in 301 BC a coalition of Cassander and the other Hellenistic kings defeated Antigonus at the
Battle of Ipsus, ending his challenge. tomb door bas
relief,
Leeds City Museum. After Cassander's death in 298 BC, however, Demetrius seized the Macedonian throne and gained control of most of Greece. He was defeated by a second coalition of Greek rulers in 285 BC, and mastery of Greece passed to the king
Lysimachus of Thrace. Lysimachus was in turn defeated and killed in 280 BC. The Macedonian throne then passed to Demetrius's son
Antigonus II, who also defeated an
invasion of the Greek lands by the
Gauls, who at this time were living in the Balkans. The battle against the Gauls united the
Antigonids of Macedon and the
Seleucids of Asia, an alliance which was also directed against the wealthiest Hellenistic power, the
Ptolemies of Egypt. The
Epirote king
Pyrrhus is known to have made
Epirus a powerful state in the wider Hellenistic world (during 297–272 BC) that was comparable to the likes of Macedon and
Ancient Rome. Pyrrhus' armies also attempted an assault against the state of Ancient Rome during their unsuccessful campaign in what is now modern-day
Italy in 280-275 BC. Pyrrhus died in 272 BC leaving Antigonus Gonatas' Macedon the stronger power in Greece. Antigonus II ruled until his death in 239 BC, and his family retained the Macedonian throne until it was abolished by the Romans in 146 BC. Their control over the Greek city states was intermittent, however, since other rulers, particularly the Ptolemies, subsidised anti-Macedonian parties in Greece to undermine the Antigonids' power. Antigonus placed a garrison at
Corinth, the strategic centre of Greece, but
Rhodes,
Pergamum,
Achaean League and
Aetolian League and other Greek states retained substantial independence.
Sparta also remained independent and generally refused to join any league. In 267 BC,
Ptolemy II persuaded the Greek cities to revolt against Antigonus, in what became the
Chremonidean War, after the Athenian leader
Chremonides. The cities were defeated and Athens lost her independence and her democratic institutions. The Aetolian League was restricted to the
Peloponnese, but on being allowed to gain control of
Thebes in 245 BC became a Macedonian ally. This marked the end of Athens as a political actor, although it remained the largest, wealthiest and most cultivated city in Greece. In 255 BC, Antigonus defeated the Ptolemaic fleet at
Cos and brought the
Aegean islands, except Rhodes, under his rule as well. ==City states and leagues==