Hosam Aiesh began his career in academy of Swedish side
BK Häcken. After spending a season on loan at the
Varbergs BolS in 2014, he joined
Östersunds FK on 1 January 2015 on a free transfer. However on 1 April 2016 he re-joined
Varbergs BolS on loan until 1 July 2016. In 2017, Aiesh managed to win his first major trophy, the
2017 Svenska Cupen, after Östersund defeated
IFK Norrköping 4–1 in the final, as a result of the victory, also qualifying for the
2017–18 UEFA Europa League, marking their first appearance in a European competition tournament. In their Europa League debut in the second qualifying round on 13 July 2017. Östersund earned a shock 2–0 victory against Turkish giants
Galatasaray at the
Jämtkraft Arena and eliminated them after a 1–1 draw in Istanbul. Aiesh's teammate
Saman Ghoddos scored 2 goals in a win against
PAOK on 24 August saw them qualify for the Group Stage at the first time of asking, After losing only one game in their campaign, they finished second in a group featuring
Athletic Bilbao and
Hertha Berlin, becoming the first Swedish club to progress beyond the Europa League group stage since UEFA rebranded the UEFA Cup into Europa League. Östersund were knocked out by English side
Arsenal, after Östersund lost the 1st leg 2–0, they beat Arsenal in the 2nd leg at the
Emirates Stadium with a 2–1 victory after a goal from Aiesh and his teammate
Ken Sema. Hosam Aiesh joined
IFK Göteborg in 2019. Hosam Aiesh joined
FC Seoul in 2023. ==International career==