Background Meredith Grey is the daughter of world-renowned
attending general surgeon, Ellis Grey (
Kate Burton), and grew up in her shadow. Ellis was a deeply flawed and neglectful mother. She moved a five-year-old Meredith from
Seattle to
Boston where she lost all contact with her father. Meredith is a graduate of
Dartmouth College. While in college, she led a
hedonistic lifestyle. Conflicts with her mother and her lack of support made Meredith question her decision to attend
medical school. That indecision led her to leave for Europe once she graduated. However, after a month abroad, Meredith was called back to care for her mother, who had developed
early-onset Alzheimer's disease. This news drove Meredith's decision to obtain her M.D.
Storylines The night before Meredith's
internship begins, she has a
one-night stand with
Derek Shepherd (
Patrick Dempsey). She discovers the next day that he is the head of
neurosurgery at her new workplace, Seattle Grace Hospital. Meredith is assigned to work under resident
Miranda Bailey (
Chandra Wilson), and befriends her fellow interns,
Cristina Yang (
Sandra Oh),
Izzie Stevens (
Katherine Heigl),
Alex Karev (
Justin Chambers) and
George O'Malley (
T.R. Knight). She is particularly close with Cristina, who becomes her best friend and "person". Though she initially thinks poorly of him, Alex also evolves into Meredith's "person" and the two assume a sibling-esque familial relationship. Meredith has a conflicted relationship with
Richard Webber (
James Pickens Jr.), the Chief of Surgery at Seattle Grace. Richard had an affair with Ellis when Meredith was a child. He often assumes a fatherly role towards her which she initially resents. Meredith resists Derek's advances at the beginning of her internship, but is eventually charmed into starting a relationship with him despite misgivings about an intern dating an attending. She is, therefore, shocked by the arrival of
Addison Montgomery (
Kate Walsh), Derek's wife, unaware that he was married. When Derek decides to return to Addison, Meredith is devastated and falls back on old habits. She tries to resolve some issues by searching for her long-absent father, Thatcher Grey (
Jeff Perry). The two do not become close, but she becomes fond of her stepmother. Meredith spirals further when Ellis is admitted to the hospital, revealing her mother's diagnosis to her colleagues, as well as her verbally abusive tendencies. Meredith's self-destructive behavior peaks when she saves a patient with a bomb inside them by impulsively inserting her hand into their chest to keep the bomb still until it can be removed. Meredith has a series of one-night stands, including one with George, who has long been in love with her. When she cries in the middle of their encounter, their friendship temporarily ends. Meredith swears off her behavior, agrees to be friends with Derek, and embarks on a relationship with veterinarian
Finn Dandridge (
Chris O'Donnell). Derek regrets his decision to return to his wife, and Meredith eventually realizes that Derek is the one, and the two of them get back together. When Ellis experiences a rare, completely lucid day and expresses her immense disappointment at how ordinary Meredith has turned out to be, Meredith becomes
depressed and
suicidal. During a ferryboat accident, Meredith is knocked into the water and chooses to give up and drown. She awakens in an "afterlife", where she interacts with deceased former acquaintances. Ellis dies in the interim, and Meredith meets with her mother, who tells her that she is anything but ordinary, before Meredith is brought back to life in the hospital. Derek distances himself from Meredith as a result of her recklessness, prompting her to seek
therapy to address her problems. She nearly fails her intern exam after a drunken Thatcher publicly blames her for the death of his wife Susan. Webber gives her a second chance to do the exam, saving her from destroying her career. After Meredith is promoted to a resident, her younger half-sister,
Lexie Grey (
Chyler Leigh), begins working at Seattle Grace as an intern. Meredith initially rejects Lexie's attempts to form a relationship, but slowly softens towards her. Meredith later initiates a neurosurgical
clinical trial, enlisting Derek as a consulting neurosurgeon. The trial fails repeatedly, but the final patient they treat survives, prompting them to reunite and move in together. Eventually, Derek and Meredith decide to marry, but on their wedding day, the pair give away their wedding ceremony to Izzie and Alex. Meredith and Derek instead marry by writing their wedding vows on a
post-it note. Meredith then spends a month out of commission after donating part of her liver to Thatcher. Meredith experiences another immense trauma after the hospital is put under lockdown from an active
mass shooter seeking revenge against Derek. Meredith offers her own life in exchange for his and
miscarries her baby during the crisis. She goes through this traumatic experience with Cristina, who operates on Derek while threatened at gunpoint, and Meredith tries to support her friend afterwards as best she can. Meredith decides to actively try to become pregnant, but learns that she has a "
hostile uterus". Meredith opts to work on Derek's clinical trial for curing Alzheimer's and she appears to be leaning towards a neuro specialty, but she endangers the trial by tampering with the drugs in an effort to help Webber's wife. She and Derek decide to adopt Zola, an orphaned baby from
Malawi, and make their marriage legal. When the truth about Meredith's tampering comes out, however, a furious Derek tells her he cannot raise a child with her because of her moral ambiguity. Meredith is fired and her behavior leads to Zola being taken away. She and Derek reconcile eventually, Meredith chooses a general surgery specialty over neuro, and they successfully fight to get Zola back. Meredith takes the
medical boards while sick with the flu. She decides to accept a job offer at The
Brigham and Women's Hospital as the next step in her career. During a flight to undertake a prestigious surgery, Meredith, Derek, Cristina, and Lexie, among others, are involved in an
aviation accident. Meredith loses her sister and the survivors are trapped in the wooded wilderness for days waiting for help. Following their rescue, Meredith becomes an
attending general surgeon at Seattle Grace, now Seattle Grace Mercy West. Meredith's strict attitude and sarcasm lead to her being dubbed "
Medusa" by the hospital's new batch of interns. Meredith, along with the other victims of the plane crash, receives $15 million in compensation from the hospital for their negligence. To prevent the hospital from going into
bankruptcy, Meredith helps buy the hospital and becomes a member of the newly renamed Grey Sloan Memorial Hospital board of directors. She also asks Dr. Bailey to perform
gene mapping on her to finally learn whether she has Alzheimer's genes like her mother. She tests positive for more than one of the
genetic markers for the disease. After construction is completed, Meredith moves with Derek into their dream house. She also discovers that she is pregnant with Derek's child once again. Meredith suffers a near miscarriage after falling down the stairs and her baby is delivered via emergency
C-section. In the aftermath, Meredith diagnoses herself as being in
disseminated intravascular coagulation and Dr. Bailey performs a
spleen removal on her, which saves her life. In return, Meredith and Derek name their son Bailey. Meredith and Cristina have a huge rift when Cristina confirms Meredith's fears by stating that Meredith's skills have fallen behind Cristina's due to her familial obligations. Meredith and Derek come to an agreement that he will take a step back to take care of the children and allow her to develop her career. Meredith attempts to regain some ground by starting a promising research trial
3-D printing portal veins. The conflict between Cristina and Meredith widens when Cristina commandeers Meredith's resources for her own trial. They later repair their relationship before Cristina moves to
Switzerland. As Meredith adjusts to life without Cristina, she finds out she has a maternal half-sister named
Maggie Pierce (
Kelly McCreary), who was given away for adoption by her mother and who is now working in Grey Sloan Memorial. Meredith retrieves repressed childhood memories of her mother being pregrant, and eventually chooses to accept Maggie and begin building a relationship. Meanwhile, Meredith and Derek's marriage becomes strained. She does not want to uproot their young family to move across the country for his career at the sacrifice of her own. Meredith ultimately encourages Derek to go work in
Washington, D.C., and he promptly leaves. Meredith proceeds to lean on her friends for support while simultaneously maintaining a streak of successful surgeries with no patient losses. Meredith and Derek agree to work things out over the phone. Meredith privately admits to Alex that she has realized that she could live independently of Derek, but chooses not to. Just as Meredith and Derek begin to rekindle their relationship, Derek is suddenly killed in a car accident. He is declared
brain dead at an understaffed hospital, and Meredith consents to removing him from life support. Following the funeral service, Meredith impulsively packs up her belongings and leaves with the children for Boston. Months pass by with parallels showing similarities in Meredith's and Ellis' lives; Meredith eventually give birth to a daughter alone like Ellis did. She names her newborn daughter after her mother. With Alex's support, she returns to Seattle with the children and is later appointed Chief of General Surgery by Bailey. She sells the "dream house" and moves back to her mother's house where she lives with Maggie and
Amelia Shepherd (
Caterina Scorsone), her sister-in-law that she considers as much of a sister as Maggie. Having settled back into life in Seattle, Meredith hosts a dinner party where her friend
Callie Torres's (
Sara Ramirez) new girlfriend Penny Blake (
Samantha Sloyan) is revealed to be the intern who worked on Derek the night he died. Meredith is upset after she finds out Penny will be working at Grey Sloan Memorial. Over time, however, she decides to effectively train Penny to be a better surgeon and forgives her. Alex and Meredith continue their close, sibling-like relationship of being each other's "person" after Cristina's departure. He supports her when she is violently attacked by a disoriented patient, while she supports him through his legal difficulties. Meredith recovers enough to start seeing
Nathan Riggs (
Martin Henderson), although their relationship is complicated by the fact that Maggie confesses to Meredith that she has feelings for Riggs. Additionally, Meredith is not ready to declare their relationship formally or publicly. Eventually, she accepts her relationship with Riggs, but it is complicated again by the unexpected return of Owen's sister, Megan Hunt (
Abigail Spencer), Riggs' fiancée, which ultimately ends their budding romance. Afterwards, Meredith is nominated for a Harper Avery Award for her groundbreaking abdominal transplant surgery on Megan. After failing to attend the awards ceremony to stay for a medical trauma, Meredith learns with all her closest friends in the OR and gallery that she has won the Harper Avery Award. After her win, Meredith throws herself into her work and is chosen to continue her project by the hospital's research contest. However, she is dragged back into her mother's past, as she meets Ellis' former best friend, Marie, who she had a falling out with. Eventually, Meredith discovers what happened in the past and is able to repair some of the damage. During Jo and Alex's wedding that Meredith ends up officiating, she is kissed by a drunken
Andrew DeLuca (
Giacomo Gianniotti), and the two brush it off. Meredith starts dating again and she is pursued by Andrew, who realized he had feelings for her. Meredith also gets interest from Atticus Lincoln (
Chris Carmack), a new orthopedic surgeon, and briefly finds herself in another love triangle. During her romantic dilemma, her estranged father, Thatcher, passes away, though they are able to make peace before his death. Eventually, Meredith chooses Andrew, and the two begin a relationship. Meredith breaks the hospital record for the longest single surgery and then begins research on an ingestible diagnostic device. While treating an underprivileged patient, Meredith commits
insurance fraud to help her. When the hospital starts investigating the case, Andrew takes the blame so that Meredith will not be sent to prison and separated from her kids. Meredith visits Andrew in jail, telling him that she loves him. She turns herself in and is sentenced to
community service, while her
medical license, though not revoked, is put in jeopardy. She misses a court date and neglects to perform some of the hours, leading to a temporary stay in jail. After a hearing is conducted, Meredith is able to keep her license and is rehired at Grey Sloan. On Meredith's first day back, she meets Cormac Hayes (
Richard Flood), the new Chief of Pediatrics, who she later learns has been sent to her by Cristina. Hayes and Meredith grow closer and bond over their shared loss of a spouse. Andrew begins showing signs of
mania, possibly brought on by
bipolar disorder, and he breaks up with Meredith when she expresses concern. Shortly after her breakup with Andrew, Meredith learns that Alex left Seattle to be with Izzie and he will not be returning. During the
COVID-19 pandemic, Meredith is stressed while coping with the high rate of deaths. She ultimately contracts
COVID-19, and while she fights for her life, she goes in and out of consciousness. During her fever dreams, which take place on a beach, she encounters several loved ones in the afterlife, including Derek, George, Andrew and Lexie. Meredith eventually recovers and gets strong enough to begin operating again. At the same time, she also takes over Richard's position as Residency Program Director. Meredith is offered the opportunity to work on a cure for
Parkinson's disease. Despite some uncertainty, she agrees to the offer on the condition that she can do the research both in Seattle and
Minnesota, where the trial is located. It is also revealed that she and Hayes briefly dated, but decided to hold off on their relationship because of problems with Hayes' son. During her time in Minnesota, Meredith runs into her former patient, a
transplant surgeon named Nick Marsh (
Scott Speedman). They bond over being miracles of medicine and start dating. Meredith begins splitting her time between Minnesota and Seattle, putting a strain on her relationship with Bailey that worsens when she is offered a full-time position at the
Mayo Clinic. Meredith prepares herself and the kids for a move to Minnesota, but her plans are halted when Bailey resigns and appoints her as the new Chief of Surgery. In the chaos, Meredith tells Nick to go back to Minnesota without her and breaks up with him. As Chief, Meredith rebuilds the halted residency program at Grey Sloan. Later, she receives an offer to work in Boston at the Fox Foundation to research Alzheimer's disease. Meredith and her kids move to Boston while she maintains a
long-distance relationship with Nick, before he eventually joins them. Her research takes a direction that puts her in conflict with her boss, Catherine Avery (
Debbie Allen). Meredith is eventually forced to surrender all of her previous findings to the Fox Foundation, while she continues researching independently. She clashes with neurosurgeon Tom Koracick (
Greg Germann), who has taken over her role at the Fox Foundation.
Personality Meredith is described as a "dark and twisty", damaged woman who sees the world in varying shades of grey. Because of this, she is an emotionally complex person. She is capable of empathizing with others when they are at their lowest points and is a sensitive observer of the people around her. At different times in her life, Meredith has suffered from various self-destructive behaviors and
mental illnesses influenced by her life circumstances:
excessive drinking,
promiscuity,
depression and
suicidal ideation. As she found more stability in her life, she became happier and more dependable, able to withstand traumas without resorting to bad habits. She continues to act impulsively at times, putting her career and even life in danger when she feels like it is the right thing to do. Meredith has a habit of "collecting strays", and allows her friends and coworkers to live in the house her mother left her. The friends she cohabitates with become her
chosen family. Meredith is endlessly loyal to her loved ones, and will bend the traditional rules of morality or professional protocol to keep them safe. As a spouse, surgeon, and mother, Meredith cites a number of times that she does not want to be like either of her parents: her unambitious father had followed her mother around pathetically before she left him, while her mother valued her career over her family. Meredith is frequently conflicted trying to
balance between the two, and fears her family are hindering her medical aspirations as much as she fears becoming like her mother whenever she is tempted to choose surgery over family.
Abilities and skills Having grown up in a hospital, Meredith shows immense natural talent. She possesses a steadfast, calm ease during medical procedures and emergencies, and is a natural observer of people. She exhibits a knack for catching subtle hints and accurately determining difficult-to-catch diagnoses. Her placid, non-judgmental
bedside manner often causes people to open up and trust her. Her surgical skills become impressive over time, and she shows a talent and patience for
medical research trials and dealing with psychologically damaged patients. Despite her initial callous treatment of residents after becoming an attending, Meredith grows into a well-respected and caring mentor, assembling a generation of interns that were considered failures and seeing their potential. Meredith's medical specialty is
general surgery. Despite this, she has participated in several clinical trials and research opportunities concerning
neurological conditions. One of her main focuses is curing
Alzheimer's disease. Meredith has proven herself as a capable general surgery attending, Chief of General Surgery and Chief of Surgery, eventually winning a Harper Avery award for her work. == Development ==