Following her graduation from Barnard College, McCreary lived in
Harlem and worked part-time at Barnard's alumnae affairs office while she continued to go on auditions and perform in plays. In 2005, McCreary made her screen debut on the
PBS animated series
Cyberchase, and later appeared on another animated PBS series,
The Electric Company. She made her
Broadway debut in the 2008 musical
Passing Strange. McCreary also had a recurring role on the
USA Network series
White Collar. In 2010, she landed a starring role in the
Off-Broadway musical comedy
Perfect Harmony. She made her film debut with a small role in the 2011 feature
Being Flynn as Inez. In 2012, she was cast in the first major role of her career, on
The CW medical series
Emily Owens, M.D., opposite
Mamie Gummer and
Aja Naomi King, playing the role of Tyra Dupre, a first-year surgical intern who is also a lesbian. However, the series was cancelled after one season. McCreary has additionally appeared on the television series
Castle,
I Just Want My Pants Back, and
Rubicon. She played the role of
Eartha Kitt in the indie film
Life opposite
Dane DeHaan and
Robert Pattinson, and also had roles in the films
Baby Baby Baby and
How to Follow Strangers. Her other stage credits include
Secret Order with the Merrimack Repertory Theater, and ''
A Midsummer Night's Dream and Eurydice'' with the Williamstown Theatre Festival. In 2014, after guest-starring in two episodes of the
Shonda Rhimes political drama
Scandal as Clare Tucker, McCreary joined Rhimes' other
ABC drama series, ''
Grey's Anatomy''. McCreary debuted in the penultimate episode of the medical drama's
tenth season titled "Everything I Try to Do, Nothing Seems to Turn Out Right" in the role of Dr.
Maggie Pierce, the half-sister of series protagonist
Meredith Grey (
Ellen Pompeo). McCreary has reprised her role in the
spin-off series
Station 19, appearing in the
crossover episodes "Under the Surface" and "Always Ready" from the second season, "I'll Be Seeing You" from the third season, and "We Build Then We Break" from the sixth season. During her ''Grey's Anatomy
hiatus in 2017, McCreary played Esther Mills in a production of the play Intimate Apparel. In 2018, McCreary booked one of the lead roles in the Netflix animated series Harvey Street Kids, where she voices the character Dot. The series premiered on June 29, 2018. A second season retitled Harvey Girls Forever!
was released on May 10, 2019. In 2018, McCreary also produced a short film titled A Cohort of Guests
featuring several of her co-stars from Grey's Anatomy
and Station 19'', and reunited with Morisseau to star as Shanita in the
Geffen Playhouse production of the playwright's
Skeleton Crew. On March 17, 2023, it was reported McCreary, who joined ''
Grey's Anatomy'' in the
tenth series as Dr.
Maggie Pierce, would be departing as a series regular following the fourteenth episode of the
nineteenth season, "Shadow of Your Love", airing on April 13, 2023. It was also announced she would be appearing in the final episode of the season, similar to Pompeo, with this marking her last appearance as a series regular. ==Personal life==