Main •
Sarayu Blue as Emet Kamala-Sweetzer •
Paul Adelstein as David Sweetzer, Emet's husband •
Madhur Jaffrey as Maya Kamala, Emet's mother •
Brian George as Sonny Kamala, Emet's father •
James Buckley as Chewey, Emet's co-worker •
Zach Cherry as Norman, Emet's co-worker •
Johnny Pemberton as Griff, Emet's co-worker
Recurring • Lily Rose Silver as Lily, Emet and David's eldest child. • Rahm Braslaw as Louie, Emet and David's middle child. In the pilot episode the character was portrayed by Callan Farris.
Guest •
Aisling Bea as Simone ("I Don't Want to Turn into My Mother"), Emet's best friend since college. The character was written out of the series following the pilot episode. • Christopher Avila as Hux ("I Don't Want to Turn into My Mother"), Emet's co-worker. The character was written out of the series following the pilot episode. • Easton Magliarditi as Tucker ("I Don't Want to Turn into My Mother") •
Jane Seymour as Chewey's Mom •
Debra Jo Rupp as Griff's Mom •
Parker Young as Damon Paul, Emet's boss •
Alfred Molina as Max, Adam's Father •
Caroline Aaron as Irene, Adam's Mother •
Taylor Misiak as Mackenzie ("I Get Sick of Being Needed") •
MYTEEN as Themself ("We're Not Fun Anymore") ==Episodes==