After making his film debut in the film,
The Grifters (1990), Adelstein went on to appear in several television series, including
Cupid,
ER,
Without a Trace, and
Scrubs, and to play a number of significant supporting roles in films such as
Bedazzled (2000),
Intolerable Cruelty (2003),
Memoirs of a Geisha (2005),
Be Cool (2005),
The Menu (2022) and
Crime 101 (2026). In 2005, he received his most significant role to date as a member of the regular cast of the suspenseful television series
Prison Break. Although he played the role of mysterious government operative
Paul Kellerman, he had originally auditioned for the role of protagonist
Lincoln Burrows. When he left the show in 2007, he joined the regular cast of the medical drama
Private Practice and stayed for the show's entire six-season run. After the series finale in 2013, he had more recently a recurring role as Leo Bergen on
Scandal, which continued into 2018. He played the main role of Jake Novak, the husband of Abby McCarthy (
Lisa Edelstein) in ''
Girlfriends' Guide to Divorce, which premiered in late 2014 as the first scripted original series for Bravo. In April 2016, he was cast as Raymond Blackstone in the Hulu series Chance'', starring
Hugh Laurie. ==Music career==